BMS587101
- CAS No.
- 509083-77-6
- Chemical Name:
- BMS587101
- Synonyms
- UNII-5V7E4UQL93;BMS 587101,BMS587101;3-Thiophenecarboxylic acid, 5-[[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl]methyl]-
- CBNumber:
- CB14919857
- Molecular Formula:
- C26H20Cl2N4O4S
- Molecular Weight:
- 555.43
- MDL Number:
- MFCD17342600
- MOL File:
- 509083-77-6.mol
| Melting point | 209-230 °C |
|---|---|
| Boiling point | 748.4±70.0 °C(Predicted) |
| Density | 1.60±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 260 mg/mL (468.11 mM; Need ultrasonic) |
| pka | 3.87±0.10(Predicted) |
| form | Solid |
| color | Off-white to light yellow |
| FDA UNII | 5V7E4UQL93 |
BMS587101 Chemical Properties,Uses,Production
Uses
BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research[1][2].
in vivo
In the mouse ovalbumin-induced lung inflammation model, BMS-587101 (0.1 mg/kg, 1.0 mg/kg, and 10 mg/kg; po.; twice a day) treatment significantly inhibits eosinophil accumulation[1].
References
[1] Dominique Potin, et al. Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function a DOI:10.1021/jm0610806
[2] Suzanne J Suchard, et al. An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis. J Immunol. 2010 Apr 1;184(7):3917-26. DOI:10.4049/jimmunol.0901095
BMS587101 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS587101 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38665 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19903 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | 3193328036@qq.com | China | 29763 | 68 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 20717 | 58 |
View Lastest Price from BMS587101 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-24 | BMS-587101
509083-77-6
|
US $1670.00-2180.00 / mg | 10g | TargetMol Chemicals Inc. |
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- BMS-587101
509083-77-6
- US $1670.00-2180.00 / mg
- TargetMol Chemicals Inc.