KU-0058684
- CAS No.
- 623578-11-0
- Chemical Name:
- KU-0058684
- Synonyms
- KU-0058684;2,5-Pyrrolidinedione, 1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorophenyl]-
- CBNumber:
- CB12731086
- Molecular Formula:
- C19H14FN3O3
- Molecular Weight:
- 351.33
- MDL Number:
- MFCD12756382
- MOL File:
- 623578-11-0.mol
KU-0058684 Chemical Properties,Uses,Production
Description
KU-0058684 is a potent PARP and DNA-PK inhibitors.
Uses
KU-0058684 is a potent PARP inhibitor, with an IC50 of 3.2 nM for PARP-1. KU-0058684 significantly reduces DNA double strand break (DSB) repair[1][2].
IC 50
PARP-1: 3.2 nM (IC50)
References
[1] Mitchell J, et al. Poly(ADP-Ribose) polymerase-1 and DNA-dependent protein kinase have equivalent roles in double strand break repair following ionizing radiation. Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1520-7. DOI:10.1016/j.ijrobp.2009.07.1722
[2] McCabe N, et al. BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency. Cancer Biol Ther. 2005 Sep;4(9):934-6. DOI:10.4161/cbt.4.9.2141
KU-0058684 Preparation Products And Raw materials
Raw materials
Preparation Products
KU-0058684 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21627 | 55 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19906 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 20036 | 58 |
| Supplier | Advantage |
|---|---|
| Henan Tianfu Chemical Co.,Ltd. | 55 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from KU-0058684 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-30 | KU-0058684
623578-11-0
|
US $2500.00-1520.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- KU-0058684
623578-11-0
- US $2500.00-1520.00 / mg
- TargetMol Chemicals Inc.