3-TERT-BUTYL-4-HYDROXYBENZONITRILE
- CAS No.
- 4910-04-7
- Chemical Name:
- 3-TERT-BUTYL-4-HYDROXYBENZONITRILE
- Synonyms
- 2-tert-Butyl-4-cyanophenol;3-TERT-BUTYL-4-HYDROXYBENZONITRILE;3-(1,1-Dimethylethyl)-4-hydroxybenzonitrile;Benzonitrile, 3-(1,1-dimethylethyl)-4-hydroxy-
- CBNumber:
- CB12603345
- Molecular Formula:
- C11H13NO
- Molecular Weight:
- 175.23
- MDL Number:
- MFCD16999179
- MOL File:
- 4910-04-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335-H412 |
| Precautionary statements | P261-P273-P305+P351+P338 |
| HS Code | 2926907090 |
3-TERT-BUTYL-4-HYDROXYBENZONITRILE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B810110 | 3-(tert-Butyl)-4-hydroxybenzonitrile | 4910-04-7 | 500mg | $175 | 2021-12-16 | Buy |
| AK Scientific | Z4791 | 3-(tert-Butyl)-4-hydroxybenzonitrile | 4910-04-7 | 1g | $188 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0389506 | 3-(TERT-BUTYL)-4-HYDROXYBENZONITRILE 95.00% | 4910-04-7 | 5MG | $496.65 | 2021-12-16 | Buy |
| AK Scientific | Z4791 | 3-(tert-Butyl)-4-hydroxybenzonitrile | 4910-04-7 | 10g | $721 | 2021-12-16 | Buy |
| Chemenu | CM117285 | 3-(tert-Butyl)-4-hydroxybenzonitrile 98% | 4910-04-7 | 25g | $991 | 2021-12-16 | Buy |
3-TERT-BUTYL-4-HYDROXYBENZONITRILE Chemical Properties,Uses,Production
Synthesis
65678-11-7
4910-04-7
The general procedure for the synthesis of 3-(tert-butyl)-4-hydroxybenzonitrile from 3-(tert-butyl)-4-hydroxybenzaldehyde is as follows: with reference to the synthesis of intermediate R10 3-(1,1-dimethylethyl)-4-hydroxybenzenecarbonitrile [1399], 3-(1,1-dimethylethyl)-4-hydroxybenzaldehyde (550 mg with reference to intermediate R9) was mixed with hydroxylamine hydrochloride (322 mg , 4.63 mmol) in 8.0 mL of acetic acid under reflux conditions for 1 hour. Upon completion of the reaction, the mixture was cooled to 0 °C and subsequently poured into ether (Et2O). The mixture was washed sequentially with water and 5% aqueous sodium hydroxide solution each. The aqueous phase was extracted twice with ether (Et2O), all organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and the solvent evaporated. The residue was ground with pentane to give 540 mg of 3-tert-butyl-4-hydroxybenzonitrile. The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ 10.92 (1H, broad single peak), 7.53-7.45 (2H, multiple peaks), 6.92 (1H, double peaks), 1.34 (9H, single peak); UPLC_ipqc analysis: retention time 1.03 min, mass spectrometry detected [M-H]-peak m/z 174.
References
[1] Patent: WO2011/69951, 2011, A1. Location in patent: Page/Page column 82-83
[2] Patent: WO2012/76877, 2012, A1. Location in patent: Page/Page column 226-227
[3] Patent: US2013/267510, 2013, A1. Location in patent: Paragraph 1399-1401
3-TERT-BUTYL-4-HYDROXYBENZONITRILE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| PharmOrgSyn Laboratories Co., Ltd. | +86-021-38228826 +86-13916602830 | sales@pharmorgsyn.cn | China | 139 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Santai Labs, Inc. | 519-85601385 | marketing@santailabs.com | China | 891 | 62 |
| Shanghai PharmOrgsyn Technology Co., LTD. | 021-+86-021-38228826 13916602830; | sales@pharmorgsyn.cn | China | 239 | 58 |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9756 | 58 | |
| Aikon International Limited | 025-58859352 18068836627 | dt3@aikonchem.com | China | 15494 | 58 |
