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ChemicalBook >> CAS DataBase List >>AGN 190299

AGN 190299

CAS No.
118292-41-4
Chemical Name:
AGN 190299
Synonyms
CS-2016;AGN 190299;Tazarotenic;Tazarotene Acid;Tazarotenic acid;Tazarotenic acid (AGN 190299);Tazarotenic Acid (10mM in DMSO);Tazarotene Impurity 1（Tazarotenic Acid）;4-Dimethylthiochroman-6-yl)ethynyl)nicotinic acid;6-(4,4-Dimethyl-thiochroman-7-ylethynyl)-nicotinic acid
CBNumber:
CB11317672
Molecular Formula:
C19H17NO2S
Molecular Weight:
323.41
MDL Number:
MFCD00872121
MOL File:
118292-41-4.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24

AGN 190299 Properties

Melting point >190°C (dec.)
Boiling point 527.5±50.0 °C(Predicted)
Density 1.31
storage temp. -20°C Freezer
solubility DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
pka 3.30±0.10(Predicted)
form Solid
color Pale Yellow to Brown
FDA UNII 85FDJ14553
UNSPSC Code 12352106
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

AGN 190299 price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21367 Tazarotenic Acid ≥98% 118292-41-4 5mg $106 2024-03-01 Buy
Cayman Chemical 21367 Tazarotenic Acid ≥98% 118292-41-4 10mg $198 2024-03-01 Buy
Cayman Chemical 21367 Tazarotenic Acid ≥98% 118292-41-4 25mg $467 2024-03-01 Buy
Cayman Chemical 21367 Tazarotenic Acid ≥98% 118292-41-4 50mg $826 2024-03-01 Buy
Usbiological 289939 Tazarotenic acid 118292-41-4 1mg $359 2021-12-16 Buy
Product number Packaging Price Buy
21367 5mg $106 Buy
21367 10mg $198 Buy
21367 25mg $467 Buy
21367 50mg $826 Buy
289939 1mg $359 Buy

AGN 190299 Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Uses

The principle active metabolite

Uses

Tazarotenic acid is the major active metabolite of Tazarotene (T010050).

Definition

ChEBI: A thiochromane that is acetylene in which the hydrogens are replaced by 5-carboxypyridin-2-yl and 4,4-dimethylthiochroman-6-yl groups. It is the active form of the prodrug tazarotene.

Biological Activity

Tazarotene is transformed to tazarotenic acid with the help of esterases. Tazarotenic acid regulates the pathogenic aspects of psoriasis through normalizing abnormal keratinocyte differentiation. It possesses strong anti-hyperproliferative effects in skin and reduces inflammation.', 'Tazarotenic acid, an active metabolite of tazarotene, is a potent and selective agonist of the retinoid receptor (RAR) th at binds to RARα, RARβ, and RARγ. Tazarotenic acid relatively selective activates RARβ and RARγ. Tazarotenic acid is a first xenobiotic substrate of human retinoic acid hydroxylase CYP26A1 and CYP26B1.

in vivo

Assessment of Pharmacokinetics (PK) profile of Tazarotenic acid (Compound AGN 190299) after an intravenous of AGN 190168 in rats[1]
.

MaleFemaleMale
Dose (mg kg-1)4.44.40.49
AUC (μg h mL-1)9.31 (2.14)9.78 (1.36)0.594 (0.95)
CL (mL min-1 kg-1)7.96 (1.59)7.62 (0.85)14.0 (2.2)
k (h-1)0.562 (0.339)0.820 (0.146) 0.741 (0.115)
T1/2 (h)1.64 (0.92)0.86 (0.14)0.95 (0.16)
V0 (L kg-1) 0.43 (0.05)0.49 (0.06)1.31 (1.15)
Vβ (L kg-1) --1.14 (0.09)
Vmax (μg min-1) 9.08 (2.89)6.09 (1.22)-
Km (μg mL-1)7.09 (1.35)5.12 (1.19)-

AGN 190299 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 86)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29730 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32249 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38653 58
China National Standard Pharmaceutical Corporation Limited 		+8615391658522 overseasales@yongstandards.com China 11922 58

View Lastest Price from AGN 190299 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tazarotenic acid pictures 2024-11-19 Tazarotenic acid
118292-41-4
 US $36.00-137.00 / mg 97.83% 10g TargetMol Chemicals Inc.
3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)- 6-((3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-3-pyridinecarboxylic acid 6-(2-(4,4-Dimethylthiochroman-6-yl)ethynyl)nicotinic acid AGN 190299 6-[[(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran)-6-yl]ethynyl]nicotinic acid Tazarotenic acid 6-[2-(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridine carboxylic acid 6-[(4,4-diMethyl-3,4-dihydro-2H-thiochroMen-6-yl)ethynyl]pyridine-3-carboxylic acid 3-Pyridinecarboxylicacid, 6-[2-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]- Tazarotene Impurity 1（Tazarotenic Acid） Tazarotenic acid (AGN 190299) 4-Dimethylthiochroman-6-yl)ethynyl)nicotinic acid TAZAROTENIC ACID; 118292-41-4; 6-(2-(4;4-DIMETHYLTHIOCHROMAN-6-YL)ETHYNYL)NICOTINIC ACID CS-2016 Tazarotene Acid Tazarotenic Acid (10mM in DMSO) Tazarotenic Acid 13C2,D2Q: What is Tazarotenic Acid 13C2,D2 Q: What is the CAS Number of Tazarotenic Acid 13C2,D2 Q: What are the applications of Tazarotenic Acid 13C2,D2 6-(4,4-Dimethyl-thiochroman-7-ylethynyl)-nicotinic acid retinoid action,inhibit,retinoic acid receptor,AGN190299,Drug Metabolite,warty dyskeratoma,AGN 190299,Tazarotenic acid,Inhibitor,Tazarotene Tazarotenic 118292-41-4 Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Retinoids Sulfur & Selenium Compounds