PF-00356231 hydrochloride
- CAS No.
- 820223-77-6
- Chemical Name:
- PF-00356231 hydrochloride
- Synonyms
- PF-0035623 hydrochloride;PF-00356231 hydrochloride;PF 00356231 hydrochloride,PF00356231 hydrochloride;(R)-3-Phenyl-3-(4-(4-(pyridin-4-yl)phenyl)thiophene-2-carboxamido)propanoic acid hydrochloride
- CBNumber:
- CB05821459
- Molecular Formula:
- C25H21ClN2O3S
- Molecular Weight:
- 464.96
- MDL Number:
- MOL File:
- 820223-77-6.mol
PF-00356231 hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0064992 | PF-00356231(hydrochloride) >99.0% | 820223-77-6 | 1mg | $155 | 2021-12-16 | Buy |
| ChemScene | CS-0064992 | PF-00356231(hydrochloride) >99.0% | 820223-77-6 | 5mg | $470 | 2021-12-16 | Buy |
| ChemScene | CS-0064992 | PF-00356231(hydrochloride) >99.0% | 820223-77-6 | 10mg | $800 | 2021-12-16 | Buy |
PF-00356231 hydrochloride Chemical Properties,Uses,Production
Uses
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1].
Biological Activity
PF-00356231 hydrochloride is a non-peptide, non-zinc-chelating matrix metalloprotease MMP-12 ligand and inhibitor (IC50=1.4 μM). It is specific for MMP-12 and forms the PF-00356231/MMP-12 complex.
in vitro
PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). It decreases the IC 50 values of MMP-12 ( 0.014 μM) and MMP-13 (0.27 μM) in the presence AH.
target
| MMP-12 < span> 1.4 μM (IC 50 ) | MMP13 0.65 nM (IC 50 ) | MMP-3 < span> 0.39 μM (IC 50 ) | MMP-8 1.7 μM (IC 50 ) | MMP-9 0.98 μM (IC 50 ) |
IC 50
MMP-12: 1.4 μM (IC50); MMP13: 0.65 nM (IC50); MMP-3: 0.39 μM (IC50); MMP-8: 1.7 μM (IC50); MMP-9: 0.98 μM (IC50)
References
[1] Morales R, et al. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J Mol Biol. 2004 Aug 20;341(4):1063-76. DOI:10.1016/j.jmb.2004.06.039
PF-00356231 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
PF-00356231 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38838 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 13681763483 | product02@bidepharm.com | China | 42446 | 60 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7786 | 56 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | 3193328036@qq.com | China | 29763 | 68 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4784 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29770 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24982 | 58 |
| Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | 2853979810@qq.com | China | 9936 | 58 |
View Lastest Price from PF-00356231 hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-18 | PF-00356231 hydrochloride
820223-77-6
|
US $65.00-316.00 / mg | 98.07% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | PF-00356231 hydrochloride
820223-77-6
|
US $65.00-316.00 / mg | 98.07% | 10g | TargetMol Chemicals Inc. |
-
- PF-00356231 hydrochloride
820223-77-6
- US $65.00-316.00 / mg
- 98.07%
- TargetMol Chemicals Inc.
-
- PF-00356231 hydrochloride
820223-77-6
- US $65.00-316.00 / mg
- 98.07%
- TargetMol Chemicals Inc.
