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ChemicalBook >> CAS DataBase List >>4-(Trifluoromethoxy)benzyl bromide

4-(Trifluoromethoxy)benzyl bromide

CAS No.
50824-05-0
Chemical Name:
4-(Trifluoromethoxy)benzyl bromide
Synonyms
1-(BROMOMETHYL)-4-(TRIFLUOROMETHOXY)BENZENE;TIMTEC-BB SBB006578;Pretomanid Impurity 4;4-(Trifluoromethoxy)benzyl;TrifluoroMethoxy BroMobenzyl;4-trifluoromethoxybromobenzyl;P-TritluromethoxybenzylBromide;4-trifluoromethoxylbenzylbromide;4-(TRIFLUOROMETHOXY)BENZYL BROMIDE;4-(Trifluoromethyloxy）benzylbromide
CBNumber:
CB0452065
Molecular Formula:
C8H6BrF3O
Molecular Weight:
255.03
MDL Number:
MFCD00061238
MOL File:
50824-05-0.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:51

4-(Trifluoromethoxy)benzyl bromide Properties

Melting point 22-24°C
Boiling point 82-84 °C10 mm Hg(lit.)
Density 1.594 g/mL at 25 °C(lit.)
refractive index n20/D 1.48(lit.)
Flash point 202 °F
storage temp. Refrigerated.
solubility soluble in Chloroform, Methanol
form Liquid or Low Melting Solid
Specific Gravity 1.594
color Clear faintly yellow
Sensitive Lachrymatory
BRN 2521451
InChI InChI=1S/C8H6BrF3O/c9-5-6-1-3-7(4-2-6)13-8(10,11)12/h1-4H,5H2
InChIKey JDNPUJCKXLOHOW-UHFFFAOYSA-N
SMILES C1(CBr)=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference 50824-05-0(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405
Hazard Codes  C
Risk Statements  34
Safety Statements  26-27-28-36/37/39-45
RIDADR  UN 3265 8/PG 2
WGK Germany  3
Hazard Note  Corrosive/Lachrymatory
HazardClass  8
PackingGroup  III
HS Code  29093090
NFPA 704
1
3 1

4-(Trifluoromethoxy)benzyl bromide price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 370622 4-(Trifluoromethoxy)benzyl bromide 97% 50824-05-0 1g $82.55 2025-07-31 Buy
Sigma-Aldrich 370622 4-(Trifluoromethoxy)benzyl bromide 97% 50824-05-0 5g $131.1 2025-07-31 Buy
TCI Chemical T1781 4-(Trifluoromethoxy)benzyl Bromide >98.0%(GC) 50824-05-0 1g $35 2025-07-31 Buy
TCI Chemical T1781 4-(Trifluoromethoxy)benzyl Bromide >98.0%(GC) 50824-05-0 5g $102 2025-07-31 Buy
TRC T774440 4-(Trifluoromethoxy)benzyl Bromide 50824-05-0 10g $195 2021-12-16 Buy
Product number Packaging Price Buy
370622 1g $82.55 Buy
370622 5g $131.1 Buy
T1781 1g $35 Buy
T1781 5g $102 Buy
T774440 10g $195 Buy

4-(Trifluoromethoxy)benzyl bromide Chemical Properties,Uses,Production

Uses

4-Trifluoromethoxybenzyl Bromide is a useful synthetic intermediate. It is used to prepare (nitro)[(trifluoromethoxy)benzyloxy]dihydroimidazo[2,1-b][1,3]oxazines with antitubercular activities. It is also used to synthesize tetrahydronaphthalenols with anti-allergic activities.

Chemical Properties

Colorless to light yellow liqui

Uses

4-(Trifluoromethoxy)benzyl bromide may be used in the synthesis of bioreductive drug, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

General Description

Polymerizations of 4-(trifluoromethoxy)benzyl bromide, via Friedel-Crafts polymerization using aluminum chloride as a catalyst has been reported.

Synthesis

4-(Trifluoromethoxy)benzyl alcohol

1736-74-9

4-(Trifluoromethoxy)benzyl bromide

50824-05-0

Synthesis of 1-(bromomethyl)-4-(trifluoromethoxy)benzene: Phosphorus tribromide (6 g, 22.2 mmol) was slowly added dropwise to a solution of (4-(trifluoromethoxy)phenyl)methanol (3.6 g, 18.8 mmol) in dichloromethane (60 mL) at 0-10 °C and stirred for 30 min. The reaction mixture was then continued to stir at room temperature for 3 hours. Upon completion of the reaction, the reaction was terminated by the addition of water (30 mL) and the mixture was washed sequentially with aqueous sodium bicarbonate (2 x 30 mL) and brine (30 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 4-trifluoromethoxybenzyl bromide (3.5 g, 66% yield) as a yellow oil.

References

[1] Patent: US2007/270434, 2007, A1. Location in patent: Page/Page column 17
[2] J. Gen. Chem. USSR (Engl. Transl.), 1965, vol. 35, p. 1631 - 1637
[3] Zhurnal Obshchei Khimii, 1965, vol. 35, p. 1628 - 1636
[4] Journal of Medicinal Chemistry, 2005, vol. 48, # 2, p. 556 - 568
[5] Organometallics, 2014, vol. 33, # 21, p. 5940 - 5943

4-(Trifluoromethoxy)benzyl bromide Preparation Products And Raw materials

Global( 388)Suppliers
Supplier Tel Email Country ProdList Advantage
Beijing Toachem Chemical Co.,Ltd
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View Lastest Price from 4-(Trifluoromethoxy)benzyl bromide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(Trifluoromethoxy)benzyl bromide pictures 2025-07-07 4-(Trifluoromethoxy)benzyl bromide
50824-05-0
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
4-(Trifluoromethoxy)benzyl bromide pictures 2025-06-27 4-(Trifluoromethoxy)benzyl bromide
50824-05-0
 US $30.00-10.00 / KG 50KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd
4-(Trifluoromethoxy)benzyl bromide pictures 2025-04-04 4-(Trifluoromethoxy)benzyl bromide
50824-05-0
 US $0.00-0.00 / KG 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
4-(TRIFLUOROMETHOXY)BENZYL BROMIDE ALPHA-BROMO-4-(TRIFLUOROMETHOXY)TOLUENE TIMTEC-BB SBB006578 P-TritluromethoxybenzylBromide 4-(Trifluoromethoxy)benzyl 4-(Trifluoromethoxy)benzyl bromide 97% 4-(Trifluoromethoxy)benzylbromide97% 4-(Trifluoromethyloxy）benzylbromide TrifluoroMethoxy BroMobenzyl 4-(Trifluoromethoxy)benzyl bromide,98% 4-BroMoMethylphenyl (trifluoroMethyl) ether 1-(Bromomethyl)-4-(trifluoromethoxy)benzene, 4-(Bromomethyl)phenyl trifluoromethyl ether Anti-Trifluoride Mathoxyphenyl Bromine Benzyl Benzene, 1-(bromomethyl)-4-(trifluoromethoxy)- Pretomanid Impurity 4 4-trifluoromethoxybromobenzyl TIANFUCHEM--50824-05-0--4-(Trifluoromethoxy)benzyl bromide 1-(BROMOMETHYL)-4-(TRIFLUOROMETHOXY)BENZENE 4-trifluoromethoxylbenzylbromide 50824-05-0 52084-05-0 C8H6BrOF3 BENZYL HALIDE Ethers Oxygen Compounds Organic Building Blocks Building Blocks Aromatic Halides (substituted) Miscellaneous Ethers Organic Building Blocks Oxygen Compounds Trifluoro-methoxy-benzene series