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Fruquintinib

Fruquintinib Struktur
1194506-26-7
CAS-Nr.
1194506-26-7
Englisch Name:
Fruquintinib
Synonyma:
CS-1643;R-228060;HMPL-013;EOS-61054;BMS-986472;Fruquintinib;Fruquintinib|HMPL-013;Fruquintinib Impurity;Fruquintinib, 10 mM in DMSO;Fruquintinib|HMPL-013 USP/EP/BP
CBNumber:
CB23037638
Summenformel:
C21H19N3O5
Molgewicht:
393.39
MOL-Datei:
1194506-26-7.mol

Fruquintinib Eigenschaften

Siedepunkt:
600.5±55.0 °C(Predicted)
Dichte
1.302±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
L?slichkeit
Soluble in DMSO (up to 5 mg/ml).
pka
14.35±0.46(Predicted)
Aggregatzustand
solid
Farbe
White
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI
InChI=1S/C21H19N3O5/c1-11-19(20(25)22-2)13-6-5-12(7-16(13)28-11)29-21-14-8-17(26-3)18(27-4)9-15(14)23-10-24-21/h5-10H,1-4H3,(H,22,25)
InChIKey
BALLNEJQLSTPIO-UHFFFAOYSA-N
SMILES
O1C2=CC(OC3=C4C(=NC=N3)C=C(OC)C(OC)=C4)=CC=C2C(C(NC)=O)=C1C
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Fruquintinib Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Fruquintinib is a VEGFR inhibitor (IC50s = 33, 35, and 0.5 nM for VEGFR1, -2, and -3, respectively). It also inhibits RET, FGFR1, and c-Kit (IC50s = 128, 181, and 458 nM, respectively) in a panel of 253 kinases. Fruquintinib inhibits VEGF-A-induced proliferation of human umbilical vein endothelial cells (HUVECs) and VEGF-C-induced proliferation of human lymphatic endothelial cells (HLECs; IC50s = 1.7 and 4.2 nM, respectively). It decreases tube formation by HUVECs by 74 and 94% when used at concentrations of 30 and 300 nM, respectively. Fruquintinib (0.5-20 mg/kg per day for 21 days) reduces tumor growth in BGC-823, HT-29, Caki-1, and NCI H460 mouse xenograft models.

Verwenden

Fruquintinib (HMPL-013) is a highly selective VEGFR-1/2/3 tyrosine kinase inhibitor. It was approved by the FDA on 8 November 2023 for the treatment of adult patients with metastatic colorectal cancer. and these patients had previously received fluoropyrimidine, oxaliplatin and irinotecan chemotherapy, anti-vascular endothelial growth factor therapy, and anti-epidermal growth factor receptor (EGFR) therapy. Fruquintinib has also been shown to improve cognitive deficits and pathological changes in a mouse model of cerebral amyloid angiopathy (CAA).

Verwenden

Fruquintinib is a multi-targeted tyrosine kinase inhibitor, a third-line regimen involved in the treatment of advanced non-small cell lung cancer in humans. Fruquintinib is a potent, highly selective and orally active inhibitor of VEGFR1, 2, 3 tyrosine kinases.

Trademarks

Fruzaqla

Fruquintinib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

6-Hydroxy-N,2-dimethylbenzofuran-3-carboxamide 4-Chloro-6,7-dimethoxyquinazoline Acetonitril Kaliumcarbonat

Downstream Produkte

Fruquintinib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 221)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139
 orders@jknbiochem.com China 5221 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368
sales@sjar-tech.com China 485 58
Jinan Jianfeng Chemical Co., Ltd 		+86-0531-88110457 +86-15562555968
 info@pharmachemm.com China 297 58
Zhengzhou Anbu Chem Co.,Ltd 		+86-0371-88006763; +8615988602810
 sales@anbuchem.com China 3000 58
Apeloa production Co.,Limited 		+8619933239880
 admin@apcl.com.cn China 861 58
Moxin Chemicals 		+8617320513646
 Anna@molcoo.com China 9882 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 33024 60
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22963 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19552 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49733 58
  • Fruquintinib|HMPL-013
  • Fruquintinib
  • 6-(6,7-dimethoxyquinazolin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide
  • HMPL-013
  • 3-Benzofurancarboxamide, 6-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-
  • 6-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-3-benzofurancarboxamide
  • R-228060
  • 6-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-1-benzofuran-3-carboxamide
  • Fruquintinib|HMPL-013 USP/EP/BP
  • EOS-61054
  • CS-1643
  • BMS-986472
  • Fruquintinib, 10 mM in DMSO
  • Fruquintinib Impurity
  • 1194506-26-7
  • Inhibitors
  • API
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