Pantoprazole Sodium
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- CAS-Nr.
- 138786-67-1
- Englisch Name:
- Pantoprazole Sodium
- Synonyma:
- PANTOZOL;Pantoloc;Protonix;Pantoprazol Sodium;Zurcal;Nolpaza;PANTECTA;EUPANTOL;Controloc;midazolesodium
- CBNumber:
- CB0415897
- Summenformel:
- C16H14F2N3NaO4S
- Molgewicht:
- 405.35
- MOL-Datei:
- 138786-67-1.mol
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Pantoprazole Sodium Eigenschaften
- Schmelzpunkt:
- 199-202°C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Pale Beige
- Stabilit?t:
- Hygroscopic
- InChI
- InChI=1S/C16H14F2N3O4S.Na/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;/h3-7,15H,8H2,1-2H3;/q-1;+1
- InChIKey
- YNWDKZIIWCEDEE-UHFFFAOYSA-N
- SMILES
- C12C=C(C=CC=1N(C(S(=O)CC1N=CC=C(OC)C=1OC)=N2)[Na])OC(F)F
- CAS Datenbank
- 138786-67-1(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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Pantoprazole Sodium Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augensch?den.
R48:Gefahr ernster Gesundheitssch?den bei l?ngerer Exposition.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White to Off-White Solid
Allgemeine Beschreibung
Pantoprazole sodium, racemicsodium5-(difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sesquihydrate is a white tooff-white crystalline powder that is freely soluble in water,very slightly soluble in phosphate buffer at pH 7.4, and practicallyinsoluble in n-hexane. The benzimidazole of this drughas a weakly basic nitrogen (pyridine N, pKa 3.83) and an benzimidazoleproton (pKa 0.11), facilitating formulation as asodium salt. The stability of the compound in aqueous solutionis pH dependent; the rate of degradation increases with decreasingpH. At ambient temperature, the degradation half-lifeis approximately 2.8 hours at pH 5.0 and approximately 220hours at pH 7.8.
The absorption of pantoprazole is rapid (C
max of2.5μg/mL, T
max 2.5 hours) after single or multiple oral40-mg doses. Pantoprazole is well absorbed (77% bioavailability).Administration with food may delay its absorptionbut does not alter pantoprazole bioavailability. Pantoprazoleis distributed mainly in extracellular fluid. The serum proteinbinding of pantoprazole is about 98%, primarily to albumin.Pantoprazole is extensively metabolized in the liver throughthe CYP system, including O-demethylation (CYP2C19),with subsequent sulfation. Other metabolic pathways includesulfur oxidation by CYP3A4. There is no evidencethat any of the pantoprazole metabolites have significantpharmacological activity. Approximately 71% of a dose of pantoprazole is excreted in the urine, with 18% excretedin the feces through biliary excretion.
Pantoprazole Sodium Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Pantoprazole Sodium Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 532)Lieferanten
138786-67-1()Verwandte Suche:
Metronidazol
5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, Dinatriumsalz, [6R-[6α,7β(Z)]]-
Cimetidin
Kaliumchlorid
Phloroglucin
Natrium
- 5-(DIFLUOROMETHOXY)-2-[[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL]SULFINYL]-1H-BENZIMIDAZOLE
- 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1h-benzimidazole sodium
- 1h-benzimidazole,5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sul
- 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1h-benzi
- midazolesodium
- EUPANTOL
- PANTOPRAZOLE SODIUM
- PANTOPRAZOLE, SODIUM SALT
- PANTECTA
- 1H-benziMidazole, 5-(difluoroMethoxy)-2-[[(3,4-diMethoxy-2-pyridinyl)Methyl]sulfinyl]-, sodiuM salt (1:1)
- Protonix sodiuM
- SKF96022 sodiuM
- sodiuM (S)-6-(difluoroMethoxy)-2-((3,4-diMethoxypyridin-2-yl)Methylsulfinyl)benzo[d]iMidazol-1-ide
- 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt sesquihydrate
- Pantozol sesquihydrate
- Protonix sesquihydrate
- 5-(difluoroMethoxy)-2-(((3,4-diMethoxypyridin-2-yl)Methyl)sulfinyl)-1H-benzo[d]iMidazole, sodiuM salt
- 6-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridyl)methylsulfinyl]-1H-benzimidazole
- PANTOPRAZOLE SODIUM POWDER
- 5-Difluoromethoxy-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt monohydrate
- Pantoprazole (as Sodium Salt)
- Eupantol, Pantecta, Pantozol, 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
- PANTOPRAZOLE SODIUM MONOHYDRATE
- Pantoprazole sodium(factory standard)
- 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridynyl)methyl]-1H-benzimidazol-1-ium sodium salt
- Controloc
- Sodium pantoprazole
- Pantaprazole SodiuM sesqhydrate IP
- 5-(DifluoroMethoxy)-2-[[(3,4-diMethoxy-2-pyridinyl)Methyl]sulfinyl]-
1H-benziMidazole SodiuM Salt
- 6-(DifluoroMethoxy)-2-[[(3,4-diMethoxy-2-pyridinyl)Methyl]sulfinyl]-1H-benziMidazole SodiuM Salt
- Nolpaza
- Zurcal
- Pantoprazole Sodium (250 mg)
- Pantoprazole Sodium Gb
- 4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1H-benzimidazole sodium
- 5-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridinyl)methylsulfinyl]benzimidazol-1-ide
- BY-1023 sodium
- BY1023 (sodium)
- 1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)
- Sodium 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide
- (+/-)-PANTOPRAZOLE, SODIUM SALT: SESQUI- HYDRATE (PYRIDYL-4-METHOXY-13C, 98%)
- Pantoprazole sodium sisquehydrate
- Pantoprazole Sodium USP/EP/BP
- Hrk 99% Pure Pharmaceutical Raw Materials Pantoprazole Sodium CAS?138786-67-1
- Pantoprazole Sodium (SKF96022)
- Pantoprazole SodiumQ: What is
Pantoprazole Sodium Q: What is the CAS Number of
Pantoprazole Sodium Q: What is the storage condition of
Pantoprazole Sodium Q: What are the applications of
Pantoprazole Sodium
- Pantoprazole Sodium BP/USP
- PANTOZOL
- Pantoloc
- Protonix
- Pantoprazol Sodium
- 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-Benzimidazole sodium salt (1:1)
- 6-(Difluoromethoxy)-2-(3,4-dimethoxy-pyridin-2-yl)methylsulfinyl-1H-benzodimidazole sodium salt
- Pantoprazole Na
(IP/BP/EP/USP)
- PENTOPRAZOLE SODIUM
- Pantoprazole sodium (USP)
- pantoprazole sodium ip/usp
- Atazanavir Impurity 46
