抗黴素A1
|
|
|
- CAS號(hào):
- 642-15-9
- 英文名:
- ANTIMYCIN A1
- 英文別名:
- ANTIMYCIN A1;dihydrosamidin;1,5-Dioxonane butanoic acid deriv.;-dioxo-1,5-dioxonan-3-yl)salicylamide;isovalericacid,8-esterwith3-formamido-n-(7-hexyl-8-hydroxy-4,9-dimethyl-2,6;3-(3-formamidosalicylamido)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl isovalerate;[3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate;[3-[(3-formamido-2-hydroxy-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate;3-methylbutyric acid [3-[(3-formamido-2-hydroxy-benzoyl)amino]-8-hexyl-4,9-diketo-2,6-dimethyl-1,5-dioxonan-7-yl] ester;3-Methylbutyric acid 3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester
- 中文名:
- 抗黴素A1
- 中文別名:
- 抗霉素A1;二氫沙米丁;二氫沙米汀;抗黴素A1;安霉素A1;抗黴素A1,二氫沙米丁
- CBNumber:
- CB9479432
- 分子式:
- C28H40N2O9
- 分子量:
- 548.63
- MOL File:
- 642-15-9.mol
|
|
|
抗黴素A1化學(xué)性質(zhì)
-
熔點(diǎn):
-
149.5℃
-
|
-
比旋光度:
-
D26 +76° (c = 1 in chloroform)
-
|
-
沸點(diǎn):
-
620.81°C (rough estimate)
-
|
-
密度:
-
1.2468 (rough estimate)
-
|
-
折射率:
-
1.5800 (estimate)
-
|
-
儲(chǔ)存條件:
-
−20°C
-
|
-
溶解度:
-
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
-
|
-
形態(tài):
-
A solid
-
|
抗黴素A1性質(zhì)、用途與生產(chǎn)工藝
Antimycin A1 是泛醇-細(xì)胞色素 c 氧化還原酶的特定電子轉(zhuǎn)移 (electron transfer) 抑制劑。Antimycin A1 通過(guò)抑制 HIF-1α 激活導(dǎo)致的 VEGF 產(chǎn)生減少來(lái)抑制血管生成。
Antimycin A, a mixture of Antimycins A1, A2, A3, and A4, is an antibiotic produced by
Streptomyces
species and displays antifungal, insecticidal, nematocidal, and piscicidal properties. Antimycin A inhibits Bcl-2 and Bcl-xL proteins, inducing apoptosis.
化學(xué)性質(zhì)
白色結(jié)晶。不溶于水，溶于乙醇，易溶于丙酮和氯仿。Mp149-150℃ (A1)，170-171.5℃(A3)；A1在乙醇中最大吸收波長(zhǎng)為226nm和320nm，A3在甲醇中最大吸收波長(zhǎng)是225nm和320nm；A1的比旋光度[α]
26D+76°(1%，氯仿)，A3為+64.3°(氯仿)。低毒，LD
50(大鼠，經(jīng)口)1469mg/kg(A1)。
用途
琥珀酸氧化酶的抑制劑，生物色素系統(tǒng)電子傳遞阻斷劑及細(xì)胞呼吸抑制劑，并具有抗病毒和抗真菌作用。
生產(chǎn)方法
鏈霉菌培養(yǎng)液經(jīng)醇提、濃縮制得復(fù)合物粗晶，再在甲醇：水：四氯化碳：己烷中逆流分配分離而得純品。
抗黴素A1
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2022/09/18 | HY-107406 | 抗黴素A1
Antimycin A1 | 642-15-9 | 500μg | 5600元 |
| 2022/09/18 | HY-107406 | 抗黴素A1
Antimycin A1 | 642-15-9 | 1mg | 9600元 |
642-15-9, 抗黴素A1 相關(guān)搜索:
- 抑制劑
- 實(shí)驗(yàn)室通用藥物
- 生物化學(xué)品
- 生化試劑
- 微生物代謝物
- C28H40N2O9
- C16H21NO2
- 安霉素A1
- 抗黴素A1,二氫沙米丁
- 抗霉素A1
- 二氫沙米丁
- 二氫沙米汀
- 抗黴素A1
- 642-15-9
- 1,5-Dioxonane butanoic acid deriv.
- 3-methylbutyric acid [3-[(3-formamido-2-hydroxy-benzoyl)amino]-8-hexyl-4,9-diketo-2,6-dimethyl-1,5-dioxonan-7-yl] ester
- [3-[(3-formamido-2-hydroxy-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate
- [3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate
- 3-Methylbutyric acid 3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester
- 3-Methylbutanoic acid 3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester
- 3-(3-formamidosalicylamido)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl isovalerate
- ANTIMYCIN A1
- isovalericacid,8-esterwith3-formamido-n-(7-hexyl-8-hydroxy-4,9-dimethyl-2,6
- -dioxo-1,5-dioxonan-3-yl)salicylamide
- dihydrosamidin