4-氨基苯基嗎啉-4-基甲酮性質(zhì)、用途與生產(chǎn)工藝

生產(chǎn)方法 

5397-76-2

51207-86-4

步驟 - (ii): (4-氨基苯基)(嗎啉代)甲酮的合成: 將中間體-8a (8.5 g, 35.9 mmol)溶于甲醇 (200 mL)中,加入10% Pd/C (850 mg),在H2氣氛下于室溫攪拌4小時。反應完成后,反應混合物通過硅藻土墊過濾,并用過量甲醇洗滌。濾液經(jīng)真空濃縮,得到淺黃色固體狀目標產(chǎn)物(7.0 g, 94.53%)。1H-NMR (400 MHz, DMSO-d6) δ: 7.12 (d, 2H, J = 8.4 Hz), 6.55 (d, 2H, J = 8.0 Hz), 5.5 (bs, 2H), 3.66-3.28 (m, 8H); MS (ES) m/z 207 (M + 1)。

參考文獻：

[1] Green Chemistry, 2018, vol. 20, # 1, p. 130 - 135

[2] Organic Letters, 2017, vol. 19, # 1, p. 194 - 197

[3] ACS Catalysis, 2015, vol. 5, # 3, p. 1526 - 1529

[4] Patent: WO2014/125410, 2014, A1. Location in patent: Page/Page column 26; 27

[5] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 9, p. 1615 - 1620

4-氨基苯基嗎啉-4-基甲酮 上下游產(chǎn)品信息

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4-氨基苯基嗎啉-4-基甲酮 生產(chǎn)廠家

51207-86-4, 4-氨基苯基嗎啉-4-基甲酮 相關搜索:

• Amines
• Pharmaceuticals
• Intermediates & Fine Chemicals
• Heterocycles
• Aromatics
• (4-氨苯基)(嗎啉)甲酮
• 4-(嗎啉-4-羰基)苯胺
• 4-(嗎啉-4-基羰基)苯胺
• (4-氨基苯基)-N-嗎啉基-甲酮
• (4-氨基苯基)-N-嗎啉基甲酮
• (4-氨基苯基)(4-嗎啉基)甲酮
• 嗎啉,4-(4-氨基苯甲酰)-
• 4-氨基苯基嗎啉-4-基甲酮
• N-(4-胺基苯酰基)嗎啡啉
• (4-氨基苯基)-嗎啉-4-甲酮
• 51207-86-4
• Methanone, (4-aminophenyl)-4-morpholinyl-
• 4-(4-Aminobenzoyl)morpholine Other Name (4-Aminophenyl)(4-morpholinyl)methanone
• 4-(morpholine-4-carbonyl)aniline
• Morpholine, 4-(4-aminobenzoyl)-
• Methanone, (4-aminophenyl)(4-morpholyl)-
• N-(p-AMinoben
• 4-(p-AMinobenzoyl)Morpholine
• 4-(4-Morpholinylcarbonyl)aniline
• 4-(4-AMinobenzoyl)Morpholine
• 1-(4-AMinophenyl)-1-Morpholin-4-ylMethanone
• p-AMinobenzoylMorpholine
• 4-(morpholin-4-ylcarbonyl)aniline(SALTDATA: FREE)
• TIMTEC-BB SBB000456
• AKOS B000462
• 4-(MORPHOLIN-4-YLCARBONYL)PHENYLAMINE
• 4-AMINOBENZOIC ACID, MORPHOLIDE
• (4-AMINOPHENYL)(MORPHOLINO)METHANONE
• (4-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE
• ART-CHEM-BB B000462
• BUTTPARK 19\02-43
• CHEMBRDG-BB 3000462