141117-12-6
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- CAS號(hào):
- 141117-12-6
- 英文名:
- Celgosivir (hydrochloride)
- 英文別名:
- MX3253 hydrochloride;MBI 3253 hydrochloride;MDL 28574 hydrochloride;Celgosivir (hydrochloride);(1S,6S,7S,8R,8aR)-1,7,8-trihydroxy-1,2,3,5,6,7,8,8a-octahydroindolizin-6-yl] butanoate
- 中文名:
- 141117-12-6
- 中文別名:
- 化合物 T10755;化合物 CELGOSIVIR HYDROCHLORIDE
- CBNumber:
- CB73167606
- 分子式:
- C12H22ClNO5
- 分子量:
- 295.76
- MOL File:
- 141117-12-6.mol
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141117-12-6化學(xué)性質(zhì)
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儲(chǔ)存條件:
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Store at -20°C
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形態(tài):
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Solid
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顏色:
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White to gray
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水溶解性:
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Water : ≥ 200 mg/mL (676.22 mM)
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141117-12-6性質(zhì)、用途與生產(chǎn)工藝
Celgosivir hydrochloride (MBI 3253 hydrochloride; MDL 28574 hydrochloride; MX3253 hydrochloride) 是 α-葡萄糖苷酶 I (α-glucosidase I) 抑制劑,在體外實(shí)驗(yàn)中的 IC50 值為 1.27 μM。
IC50: 1.27 μM (α-glucosidase I)
Celgosivir is more effective (IC
50
=20 μM) than the parent molecule (IC
50
=254 μM) at causing the accumulation of glucosylated oligosaccharides in HIV-infected cells by inhibition of glycoprotein processing. Celgosivir exhibits potent antiviral activity against HIV-1 with an IC
50
of 2.0±2.3 μM. Bovine viral diarrhoea virus (BVDV) is a closely related virus of hepatitis C virus (HCV). Celgosivir inhibits BVDV with IC
50
values of 16 and 47 μM in plaque assay and cytopathic effect assay, respectively. Celgosivir inhibits DENV2 replication with an EC
50
of 0.2 μM. The EC
50
values against DENV1, 3 and 4 are less than 0.7 μM.
Celgosivir fully protects AG129 mice from lethal infection with a mouse adapted dengue virus at a dose of 50 mg/kg twice daily (BID) for 5 days and is effective even after 48 h delayed treatment. The protection by celgosivir is dose- and schedule-dependent and that a twice-a-day regimen of 50, 25 or 10 mg/kg is more protective than a single daily dose of 100 mg/kg. Pharmacokinetics studies of celgosivir in mice shows that it rapidly metabolizes to castanospermine. During primary infection with a mouse-adapted DENV strain S221, mice shows increased viremia on day 3, yet 80% survived day 10 with virus completely cleared by day 8.
141117-12-6
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更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS編號(hào) | 包裝 | 價(jià)格 |
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2025/05/22 | HY-16134A | 141117-12-6 Celgosivir hydrochloride | 141117-12-6 | 5mg | 1700元 |
2025/05/22 | HY-16134A | 141117-12-6 Celgosivir hydrochloride | 141117-12-6 | 10mM * 1mLin DMSO | 1870元 |
141117-12-6, 141117-12-6 相關(guān)搜索:
- 抑制劑
- 化合物 CELGOSIVIR HYDROCHLORIDE
- 化合物 T10755
- 141117-12-6
- (1S,6S,7S,8R,8aR)-1,7,8-trihydroxy-1,2,3,5,6,7,8,8a-octahydroindolizin-6-yl] butanoate
- MX3253 hydrochloride
- MDL 28574 hydrochloride
- MBI 3253 hydrochloride
- Celgosivir (hydrochloride)