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SR 146131

SR 146131, 221671-61-0, 結(jié)構(gòu)式
SR 146131
CAS號:
221671-61-0
英文名:
SR 146131
英文別名:
SR 146131;NFDFTMICKVDYLQ-UHFFFAOYSA-N;1H-Indole-1-acetic acid, 2-[[[4-(4-chloro-2,5-dimethoxyphenyl)-5-(2-cyclohexylethyl)-2-thiazolyl]amino]carbonyl]-5,7-dimethyl-
中文名:
SR 146131
中文別名:
化合物 T16935
CBNumber:
CB52628425
分子式:
C32H36ClN3O5S
分子量:
610.16
MOL File:
221671-61-0.mol

SR 146131化學(xué)性質(zhì)

密度:
1.35±0.1 g/cm3(Predicted)
儲存條件:
Store at -20°C
溶解度:
Soluble in DMSO
形態(tài):
Solid
酸度系數(shù)(pKa):
4.01±0.10(Predicted)
顏色:
White to off-white
安全信息

SR 146131性質(zhì)、用途與生產(chǎn)工藝

生物活性

SR 146131是一種有效,有口服活性,選擇性的非多肽縮膽囊素1 (cholecystokinin 1)受體激動劑。

靶點

Cholecystokinin 1 receptor

體外研究

SR 146131 inhibits in the binding of [ 125 I]-BH-CCK-8S to CCK1sites on 3T3-hCCK1 cell membranes with an IC 50 value of 0.56 ± 0.10 nM. At much higher concentrations, SR 146131 also inhibits the binding of radiolabeled CCK to CCK2sites in CHO-hCCK2 membranes with an IC 50 of 162 ± 27 nM. SR 146131 is a potent CCK1 agonist on several intracellular events linked to CCK1 receptor activation in various cell types: on [Ca 2+ ]i release and IP1 formation, SR 146131 appears as a full CCK1 receptor agonist in the 3T3-hCCK1 cells, but a partial CCK1receptor agonist on MAPK activation and early gene expression in this cell line. SR 146131 also acts as a partial agonist in the two neuroblastoma cell lines.

體內(nèi)研究

SR 146131 completely inhibits gastric and gallbladder emptying in mice (ED 50 of 66 and 2.7 μg/kg p.o., respectively). SR 146131 dose dependently reduces food intake in fasted rats (from 0.1 mg/kg p.o.), in nonfasted rats in which food intake has been highly stimulated by the administration of neuropeptide Y (1–36) (from 0.3 mg/kg p.o.), in fasted gerbils (from 0.1 mg/kg p.o.), and in marmosets maintained on a restricted diet (from 3 mg/kg p.o.). SR 146131 (10 mg/kg p.o.) also increases the number of Fos-positive cells in the hypothalamic paraventricular nucleus of rats. Locomotor activity of mice is reduced by orally administered SR 146131 (from 0.3 mg/kg p.o.).

SR 146131 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

SR 146131 試劑級價格

更新日期產(chǎn)品編號產(chǎn)品名稱CAS編號包裝價格
2025/05/22HY-11077SR 146131221671-61-01 mg2000元
2025/05/22HY-11077SR 146131
SR 146131
221671-61-05mg5000元

SR 146131 生產(chǎn)廠家

全球有 8家供應(yīng)商   SR 146131國內(nèi)生產(chǎn)廠家
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范德(北京)生物科技有限責(zé)任公司 15911056312 liming@bio-fount.com 中國 9729 58
TargetMol Chemicals Inc. +17819995354 marketing@targetmol.com 美國 32371 58
天津普西唐生物醫(yī)藥科技有限公司 010-60605840 15801484223 psaitong@jm-bio.com 中國 29770 58
南京世洲生物科技有限公司 025-85560043 15850508050 cindy.huang@synzest.com 中國 12000 58
銳迪國際科技有限公司 18024082417 market@ubiochem.com 中國 9835 58
南京百鑫德諾生物科技有限公司 400-025-6535 sales@adooq.cn 中國 6215 58
廣州芯銳生物科技有限公司 18027212158 中國 0 58
 

221671-61-0, SR 146131 相關(guān)搜索:

  • C32H36ClN3O5S
  • 化合物 T16935
  • 221671-61-0
  • 1H-Indole-1-acetic acid, 2-[[[4-(4-chloro-2,5-dimethoxyphenyl)-5-(2-cyclohexylethyl)-2-thiazolyl]amino]carbonyl]-5,7-dimethyl-
  • NFDFTMICKVDYLQ-UHFFFAOYSA-N
  • SR 146131
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