SR 146131
|
|
- CAS號:
- 221671-61-0
- 英文名:
- SR 146131
- 英文別名:
- SR 146131;NFDFTMICKVDYLQ-UHFFFAOYSA-N;1H-Indole-1-acetic acid, 2-[[[4-(4-chloro-2,5-dimethoxyphenyl)-5-(2-cyclohexylethyl)-2-thiazolyl]amino]carbonyl]-5,7-dimethyl-
- 中文名:
- SR 146131
- 中文別名:
- 化合物 T16935
- CBNumber:
- CB52628425
- 分子式:
- C32H36ClN3O5S
- 分子量:
- 610.16
- MOL File:
- 221671-61-0.mol
|
|
|
SR 146131化學(xué)性質(zhì)
-
密度:
-
1.35±0.1 g/cm3(Predicted)
-
|
-
儲存條件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形態(tài):
-
Solid
-
|
-
酸度系數(shù)(pKa):
-
4.01±0.10(Predicted)
-
|
-
顏色:
-
White to off-white
-
|
SR 146131性質(zhì)、用途與生產(chǎn)工藝
SR 146131是一種有效,有口服活性,選擇性的非多肽縮膽囊素1 (cholecystokinin 1)受體激動劑。
Cholecystokinin 1 receptor
SR 146131 inhibits in the binding of [
125
I]-BH-CCK-8S to CCK1sites on 3T3-hCCK1 cell membranes with an IC
50
value of 0.56 ± 0.10 nM. At much higher concentrations, SR 146131 also inhibits the binding of radiolabeled CCK to CCK2sites in CHO-hCCK2 membranes with an IC
50
of 162 ± 27 nM. SR 146131 is a potent CCK1 agonist on several intracellular events linked to CCK1 receptor activation in various cell types: on [Ca
2+
]i release and IP1 formation, SR 146131 appears as a full CCK1 receptor agonist in the 3T3-hCCK1 cells, but a partial CCK1receptor agonist on MAPK activation and early gene expression in this cell line. SR 146131 also acts as a partial agonist in the two neuroblastoma cell lines.
SR 146131 completely inhibits gastric and gallbladder emptying in mice (ED
50
of 66 and 2.7 μg/kg p.o., respectively). SR 146131 dose dependently reduces food intake in fasted rats (from 0.1 mg/kg p.o.), in nonfasted rats in which food intake has been highly stimulated by the administration of neuropeptide Y (1–36) (from 0.3 mg/kg p.o.), in fasted gerbils (from 0.1 mg/kg p.o.), and in marmosets maintained on a restricted diet (from 3 mg/kg p.o.). SR 146131 (10 mg/kg p.o.) also increases the number of Fos-positive cells in the hypothalamic paraventricular nucleus of rats. Locomotor activity of mice is reduced by orally administered SR 146131 (from 0.3 mg/kg p.o.).
SR 146131
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
---|
2025/05/22 | HY-11077 | SR 146131 | 221671-61-0 | 1 mg | 2000元 |
2025/05/22 | HY-11077 | SR 146131 SR 146131 | 221671-61-0 | 5mg | 5000元 |
221671-61-0, SR 146131 相關(guān)搜索:
- C32H36ClN3O5S
- 化合物 T16935
- 221671-61-0
- 1H-Indole-1-acetic acid, 2-[[[4-(4-chloro-2,5-dimethoxyphenyl)-5-(2-cyclohexylethyl)-2-thiazolyl]amino]carbonyl]-5,7-dimethyl-
- NFDFTMICKVDYLQ-UHFFFAOYSA-N
- SR 146131