2-二氟甲基-4-溴吡啶
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- CAS號(hào):
- 1211580-54-9
- 英文名:
- 4-Bromo-2-(difluoromethyl)pyridine
- 英文別名:
- 4-Bromo-2-(difL;4-Bromo-2-(difluoromethyl)pyridine;Pyridine, 4-bromo-2-(difluoromethyl)-;4-Bromo-2-(difluoromethyl)pyridine 97%;4-Bromo-alpha,alpha-difluoro-2-picoline
- 中文名:
- 2-二氟甲基-4-溴吡啶
- 中文別名:
- 4-溴-2-二氟甲基吡啶;2-二氟甲基-4-溴吡啶;4-BROMO-2-(DIFLUOROMETHYL)PYRIDINE 4-溴-2-(二氟甲基)吡啶 CAS:1211580-54-9
- CBNumber:
- CB42688471
- 分子式:
- C6H4BrF2N
- 分子量:
- 208
- MOL File:
- 1211580-54-9.mol
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2-二氟甲基-4-溴吡啶化學(xué)性質(zhì)
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沸點(diǎn):
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210.3±35.0 °C(Predicted)
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密度:
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1.640±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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under inert gas (nitrogen or Argon) at 2-8°C
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酸度系數(shù)(pKa):
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0.27±0.10(Predicted)
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形態(tài):
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liquid
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顏色:
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Colourless to light yellow
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InChI:
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InChI=1S/C6H4BrF2N/c7-4-1-2-10-5(3-4)6(8)9/h1-3,6H
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InChIKey:
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MNMLGZMORMDPJI-UHFFFAOYSA-N
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SMILES:
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C1(C(F)F)=NC=CC(Br)=C1
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2-二氟甲基-4-溴吡啶性質(zhì)、用途與生產(chǎn)工藝
生產(chǎn)方法
步驟1:4-溴-2-(二氟甲基)吡啶的合成:在室溫下,向4-溴吡啶-2-甲醛(5.0 g,26.88 mmol)中加入二乙氨基三氟化硫(7.03 mL,53.7 mmol),并將反應(yīng)混合物攪拌16小時(shí)。反應(yīng)完成后,用碳酸氫鈉水溶液(50 mL)淬滅反應(yīng),隨后用乙酸乙酯(3×100 mL)萃取。合并有機(jī)層,用鹽水(2×50 mL)洗滌,經(jīng)無水硫酸鈉干燥,過濾并濃縮。通過硅膠柱色譜(100-200目)純化,使用5%乙酸乙酯的己烷溶液作為洗脫劑,得到4-溴-2-(二氟甲基)吡啶(3.0 g,14.492 mmol,54%收率)。1H NMR(400 MHz,CDCl3)δ= 8.48(d,J = 4.9 Hz,1H),7.82(d,J = 1.5 Hz,1H),7.66-7.50(m,1H),6.60(t,1H)。LCMS:207.9 [M + H]+。
參考文獻(xiàn):
[1] Patent: WO2016/161160, 2016, A1. Location in patent: Paragraph 0207
[2] Patent: US2015/152108, 2015, A1. Location in patent: Paragraph 0480; 0481
[3] Patent: WO2016/79709, 2016, A1. Location in patent: Page/Page column 179
[4] Patent: US2010/125082, 2010, A1. Location in patent: Page/Page column 24; 25
[5] Patent: WO2015/180612, 2015, A1. Location in patent: Page/Page column 78
2-二氟甲基-4-溴吡啶
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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2025/05/22 | XW02121158054903 | 4-溴-2-(二氟甲基)吡啶 | 1211580-54-9 | 1G | 131元 |
2025/05/22 | XW02121158054902 | 4-溴-2-(二氟甲基)吡啶 | 1211580-54-9 | 250MG | 38元 |
1211580-54-9, 2-二氟甲基-4-溴吡啶 相關(guān)搜索:
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- 4-BROMO-2-(DIFLUOROMETHYL)PYRIDINE 4-溴-2-(二氟甲基)吡啶 CAS:1211580-54-9
- 4-溴-2-二氟甲基吡啶
- 2-二氟甲基-4-溴吡啶
- 1211580-54-9
- Pyridine, 4-bromo-2-(difluoromethyl)-
- 4-Bromo-2-(difL
- 4-Bromo-2-(difluoromethyl)pyridine 97%
- 4-Bromo-2-(difluoromethyl)pyridine
- 4-Bromo-alpha,alpha-difluoro-2-picoline