BAY1834845
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- CAS號:
- 1931994-81-8
- 英文名:
- 2-Pyridinecarboxamide, N-[6-(1-hydroxy-1-methylethyl)-2-[2-(methylsulfonyl)ethyl]-2H-indazol-5-yl]-6-(trifluoromethyl)-
- 英文別名:
- BAY-845;BAY-1834845;Zabedosertib;Zabedosertib, 10 mM in DMSO;N-(6-(2-Hydroxypropan-2-yl)-2-(2-(methylsulfonyl)ethyl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide;N-[6-(2-Hydroxy-2-propyl)-2-[2-(methylsulfonyl)ethyl]-2H-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide;N-[6-(1-hydroxy-1-methyl-ethyl)-2-(2-methylsulfonylethyl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide;2-Pyridinecarboxamide, N-[6-(1-hydroxy-1-methylethyl)-2-[2-(methylsulfonyl)ethyl]-2H-indazol-5-yl]-6-(trifluoromethyl)-
- 中文名:
- BAY1834845
- 中文別名:
- BAY1834845;Zabedosertib 試劑;Zabedosertib 試劑;化合物 ZABEDOSERTIB;BAY-1834845;BAY-845;化合物ZABEDOSERTIB,10 MM DMSO 溶液;N-[6-(1-羥基-1-甲基乙基)-2-(2-甲基磺酰乙基)吲唑-5-基]-6-(三氟甲基)吡啶-2-甲酰胺;N-(6-(2-羥基丙-2-基)-2-(2-(甲基磺?；?乙基)-2H-吲唑-5-基)-6-(三氟甲基)吡啶-2-甲酰胺;N-[6-(2-羥基-2-丙基)-2-[2-(甲基磺?；?乙基]-2H-吲唑-5-基]-6-(三氟甲基)吡啶-2-甲酰胺
- CBNumber:
- CB38237502
- 分子式:
- C20H21F3N4O4S
- 分子量:
- 470.47
- MOL File:
- 1931994-81-8.mol
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BAY1834845化學性質
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沸點:
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620.7±55.0 °C(Predicted)
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密度:
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1.44±0.1 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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DMSO : 125 mg/mL (265.69 mM; ultrasonic and warming and heat to 60°C)
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酸度系數(pKa):
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11.53±0.43(Predicted)
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形態(tài):
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Solid
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顏色:
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White to off-white
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BAY1834845性質、用途與生產工藝
Zabedosertib (BAY 1834845) 是一種選擇性的，口服有效的 IRAK4 抑制劑，具有免疫調節(jié)潛能，IC50 值為 3.55 nM。IRAK4 是一種參與 toll 樣受體的先天免疫反應信號的蛋白激酶。Zabedosertib 對 IL-β，LPS (HY-D1056) 和 Imiquimod (HY-B1080) 誘導的炎癥具有抗炎作用。
BAY1834845
上下游產品信息
上游原料
下游產品
| 更新日期 | 產品編號 | 產品名稱 | CAS編號 | 包裝 | 價格 |
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| 2025/05/22 | HY-139374 | Zabedosertib | 1931994-81-8 | 1 mg | 320元 |
| 2025/05/22 | HY-139374 | 2-Pyridinecarboxamide, N-[6-(1-hydroxy-1-methylethyl)-2-[2-(methylsulfonyl)ethyl]-2H-indazol-5-yl]-6-(trifluoromethyl)-
Zabedosertib | 1931994-81-8 | 5mg | 714元 |
1931994-81-8, BAY1834845 相關搜索:
- 抑制劑
- Zabedosertib 試劑
- Zabedosertib 試劑
- BAY-1834845;BAY-845
- 化合物ZABEDOSERTIB,10 MM DMSO 溶液
- 化合物 ZABEDOSERTIB
- N-(6-(2-羥基丙-2-基)-2-(2-(甲基磺酰基)乙基)-2H-吲唑-5-基)-6-(三氟甲基)吡啶-2-甲酰胺
- N-[6-(2-羥基-2-丙基)-2-[2-(甲基磺?；?乙基]-2H-吲唑-5-基]-6-(三氟甲基)吡啶-2-甲酰胺
- N-[6-(1-羥基-1-甲基乙基)-2-(2-甲基磺酰乙基)吲唑-5-基]-6-(三氟甲基)吡啶-2-甲酰胺
- BAY1834845
- 1931994-81-8
- BAY-845
- Zabedosertib, 10 mM in DMSO
- N-[6-(2-Hydroxy-2-propyl)-2-[2-(methylsulfonyl)ethyl]-2H-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide
- N-(6-(2-Hydroxypropan-2-yl)-2-(2-(methylsulfonyl)ethyl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide
- N-[6-(1-hydroxy-1-methyl-ethyl)-2-(2-methylsulfonylethyl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide
- Zabedosertib
- BAY-1834845
- 2-Pyridinecarboxamide, N-[6-(1-hydroxy-1-methylethyl)-2-[2-(methylsulfonyl)ethyl]-2H-indazol-5-yl]-6-(trifluoromethyl)-