黃花夾竹桃黃酮
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- CAS號:
- 29376-68-9
- 英文名:
- Thevetiaflavone
- 英文別名:
- Thevetiaflavone;5-O-METHYLAPIGENIN;Apigenin 5-methylether;Apigenin 5-O-monomethyl ether;4',7-Dihydroxy-5-methoxyflavone;Flavone,4',7-dihydroxy-5-methoxy- (8CI);Apigenin-5-methyl ether,5-0-Methylapigenin;7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one;4H-1-Benzopyran-4-one,7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-;ethylprop-2-enoate,2-methylprop-2-enoicacid,propane-1,2-diol,styrene
- 中文名:
- 黃花夾竹桃黃酮
- 中文別名:
- 黃花夾竹桃黃酮;芹菜素-5-甲醚;化合物 T13922
- CBNumber:
- CB2748959
- 分子式:
- C16H12O5
- 分子量:
- 284.26
- MOL File:
- Mol file
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黃花夾竹桃黃酮化學(xué)性質(zhì)
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熔點:
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263℃
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沸點:
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567.9±50.0 °C(Predicted)
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密度:
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1.420
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儲存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系數(shù)(pKa):
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6.67±0.40(Predicted)
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形態(tài):
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Solid
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顏色:
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Light yellow to yellow
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黃花夾竹桃黃酮性質(zhì)、用途與生產(chǎn)工藝
黃花夾竹桃黃酮抑制兔中性白細胞分泌β-葡萄糖醛酸酶，ED50為20μM；黃花夾竹桃黃酮抑制肌質(zhì)網(wǎng)狀組織Ca2+-ATPase，濃度為100μM時，抑制率69%。
從刺山柑中獲得精制提取物的方法，其特征在于，該方法包括以下步驟：a)使?jié)饪s的刺山柑粗提物上大孔吸附樹脂層析，依次用水和20-30％的乙醇溶液洗脫；b)再用50-100％的乙醇溶液洗脫，即得刺山柑精制提取物。所述總吲哚的主要化學(xué)成分為6-methoxybrassicanalA、6-methoxyspirobrassinin、3-醛基吲哚、3-醛基-4-羥基吲哚和Arvelexin。所述總黃酮的主要化學(xué)成分為槲皮素-3-蕓香糖苷、山奈酚-3-蕓香糖苷、黃花夾竹桃黃酮、金圣草素、櫻花素、銀杏黃素和異銀杏黃素。
Thevetiaflavone 可以上調(diào) Bcl?2 的表達，下調(diào) Bax 和 caspase-3 的表達。
Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS?mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca
2+
level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl?2 and downregulating that of Bax and caspase?3 in addition to increasing the activity of caspase?3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic.
黃花夾竹桃黃酮
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2025/05/22 | HY-N1157 | 黃花夾竹桃黃酮
Thevetiaflavone | 29376-68-9 | 1 mg | 3200元 |
| 2024/08/19 | HY-N1157 | Thevetiaflavone | | 5 mg | 8000元 |
29376-68-9, 黃花夾竹桃黃酮 相關(guān)搜索:
- Miscellaneous Natural Products
- 抑制劑
- 類固醇
- 黃酮
- 芹菜素-5-甲醚
- 化合物 T13922
- 黃花夾竹桃黃酮
- 29376-68-9
- Thevetiaflavone
- ethylprop-2-enoate,2-methylprop-2-enoicacid,propane-1,2-diol,styrene
- Flavone,4',7-dihydroxy-5-methoxy- (8CI)
- Apigenin-5-methyl ether,5-0-Methylapigenin
- Apigenin 5-O-monomethyl ether
- 4H-1-Benzopyran-4-one,7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-
- 7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one
- Apigenin 5-methylether
- 4',7-Dihydroxy-5-methoxyflavone
- 5-O-METHYLAPIGENIN