氯非銨甲苯磺酸鹽
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- CAS號(hào):
- 92953-10-1
- 英文名:
- CLOFILIUM TOSYLATE
- 英文別名:
- CLOFILIUM TOSYLATE;Clofilium tosylate, 10 mM in DMSO;4-CHLORO-N,N-DIETHYL-N-HEPTYLBENZENEBUTANAMINIUM TOSYLATE;4-chloro-n,n-diethyl-n-heptyl-benzenebutanaminiusaltwith4-methylbenzenes;Clofilium tosylate,Potassium Channel,Clofilium,inhibit,Apoptosis,Inhibitor,KcsA;N-(4-(4-CHLOROPHENYL)BUTYL)-N,N-DIETHYLHEPTAN-1-AMINIUM 4-METHYLBENZENESULFONATE
- 中文名:
- 氯非銨甲苯磺酸鹽
- 中文別名:
- 氯非銨甲苯磺酸鹽;氯非銨甲苯磺酸鹽,10 MM DMSO 溶液;N-(4-(4-氯苯基)丁基)-N,N-二乙基庚烷-1-銨 4-甲基苯磺酸鹽
- CBNumber:
- CB2435110
- 分子式:
- C28H44ClNO3S
- 分子量:
- 510.17
- MOL File:
- 92953-10-1.mol
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氯非銨甲苯磺酸鹽化學(xué)性質(zhì)
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儲(chǔ)存條件:
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4°C, protect from light
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溶解度:
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H2O: soluble
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形態(tài):
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solid
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顏色:
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white
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水溶解性:
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H2O: soluble
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氯非銨甲苯磺酸鹽性質(zhì)、用途與生產(chǎn)工藝
Clofilium tosylate 是一種鉀通道 (potassium channel) 阻滯劑，作用于人早幼粒細(xì)胞白血病 (HL-60) 細(xì)胞，激活 caspase-3 而誘導(dǎo)凋亡。具有抗心律失常作用。
HL-60 cells treated with Clofilium (0-20 μM; 24, 48, and 72 hours) lead to suppression of viability and proliferation in both time and concentration-dependent manners. Cell viability decreases significantly in HL-60 cells treated with 2.5 μM to 10 μM of Clofilium.
Clofilium (10 μM, 12 hours) induces the proteolytic cleavage of inactive procaspase-3, p34 into its active form, p17 and subsequent cleavage of its substrate PARP at 2 h after exposure to 10 mM Clofilium. However, there is no significant change in expression of Bcl-2 and Bax proteins.
Cell Viability Assay
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Cell Line:
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HL-60 cells
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Concentration:
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0-20 μM
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Incubation Time:
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24, 48, and 72 hours
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Result:
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Inhibited HL-60 cells with IC
50
s of 6.3 μM for 24 hours, 3.4 μM for 48 hours, 2.4 μM for 72 hours, respectively.
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Western Blot Analysis
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Cell Line:
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HL-60 cells
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Concentration:
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10 μM
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Incubation Time:
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12 hours
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Result:
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Induced proteolytic cleavage of caspase-3 and subsequent cleavage of its substrate, PARP, while Bcl-2 and Bax proteins were unaltered.
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氯非銨甲苯磺酸鹽
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2025/05/22 | HY-33350 | 氯非銨甲苯磺酸鹽
Clofilium tosylate | 92953-10-1 | 1 mg | 308元 |
| 2025/05/22 | HY-33350 | 氯非銨甲苯磺酸鹽
Clofilium tosylate | 92953-10-1 | 5 mg | 728元 |
氯非銨甲苯磺酸鹽
生產(chǎn)廠(chǎng)家
92953-10-1, 氯非銨甲苯磺酸鹽 相關(guān)搜索:
- 抑制劑
- C21H37ClNC7H7O3S
- 氯非銨甲苯磺酸鹽,10 MM DMSO 溶液
- N-(4-(4-氯苯基)丁基)-N,N-二乙基庚烷-1-銨 4-甲基苯磺酸鹽
- 氯非銨甲苯磺酸鹽
- 92953-10-1
- Clofilium tosylate, 10 mM in DMSO
- Clofilium tosylate,Potassium Channel,Clofilium,inhibit,Apoptosis,Inhibitor,KcsA
- N-(4-(4-CHLOROPHENYL)BUTYL)-N,N-DIETHYLHEPTAN-1-AMINIUM 4-METHYLBENZENESULFONATE
- 4-CHLORO-N,N-DIETHYL-N-HEPTYLBENZENEBUTANAMINIUM TOSYLATE
- 4-chloro-n,n-diethyl-n-heptyl-benzenebutanaminiusaltwith4-methylbenzenes
- CLOFILIUM TOSYLATE