IITZ-01
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- CAS號:
- 1807988-47-1
- 英文名:
- IITZ-01
- 英文別名:
- IITZ-01;CS-2857;IITZ-01 ，S8764;IITZ-01, 10 mM in DMSO;Autophagy inhibitor IITZ-01;AUTOPHAGY INHIBITOR;IITZ 01;IITZ01;AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01;Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K;N2-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine;N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine
- 中文名:
- IITZ-01
- 中文別名:
- 化合物IITZ-01;IITZ-01 ,S8764;化合物IITZ-01,10 MM DMSO 溶液;N2-(4-(1H-苯并[D]咪唑-2-基)苯基)-N4-(4-氟苯基)-6-嗎啉代-1,3,5-三嗪-2,4-二胺
- CBNumber:
- CB04668033
- 分子式:
- C26H23FN8O
- 分子量:
- 482.51
- MOL File:
- 1807988-47-1.mol
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IITZ-01化學性質(zhì)
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沸點:
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747.0±70.0 °C(Predicted)
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密度:
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1.420±0.06 g/cm3(Predicted)
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儲存條件:
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under inert gas (nitrogen or Argon) at 2–8 °C
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溶解度:
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DMSO:100.0(Max Conc. mg/mL);207.24(Max Conc. mM)
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酸度系數(shù)(pKa):
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11.55±0.10(Predicted)
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形態(tài):
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Solid
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顏色:
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White to off-white
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IITZ-01性質(zhì)、用途與生產(chǎn)工藝
IITZ-01 是一個具有抗腫瘤活性的、有效的親溶酶體的自噬抑制劑，其對 PI3Kγ 的 IC50 值為 2.62 μM。
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PI3Kγ
2.62 μM (IC
50
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Autophagy
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IITZ-01 (0-2 μM, 24 h) enhances autophagosomes formation as indicated by increased expression of LC3-II levels time- and dose-dependently in triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453). IITZ-01 also demonstrates potent autophagy inhibitory activity in other breast, lung, and colon cancer cells.
Western Blot Analysis
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Cell Line:
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Triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453).
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Concentration:
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0-2 μM.
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Incubation Time:
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24 hours.
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Result:
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Enhanced autophagosomes formation as indicated by increased expression of LC3-II levels.
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IITZ-01 (45 mg/kg, i.p. every alternate day for 4 weeks) inhibits average breast tumor growth when compared with control from third day of treatment in triple-negative breast tumor models in mice.
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Animal Model:
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MDA-MB-231 (TNBC)/green fluorescent protein (GFP) orthotropic breast cancer xenografts were developed in CrTac:NCr-Foxn
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BALB/c female nude mice.
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Dosage:
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45 mg/kg.
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Administration:
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Intraperitoneal every alternate day for 4 weeks.
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Result:
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Inhibited average breast tumor growth when compared with control from third day of treatment.
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IITZ-01
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2025/05/22 | HY-112897 | IITZ-01
IITZ-01 | 1807988-47-1 | 5mg | 700元 |
| 2025/05/22 | HY-112897 | IITZ-01
IITZ-01 | 1807988-47-1 | 10mM * 1mLin DMSO | 740元 |
1807988-47-1, IITZ-01 相關(guān)搜索:
- API
- 抑制劑
- 高端化學
- C26H23FN8O
- IITZ-01 ,S8764
- 化合物IITZ-01,10 MM DMSO 溶液
- 化合物IITZ-01
- N2-(4-(1H-苯并[D]咪唑-2-基)苯基)-N4-(4-氟苯基)-6-嗎啉代-1,3,5-三嗪-2,4-二胺
- 1807988-47-1
- IITZ-01 ，S8764
- IITZ-01, 10 mM in DMSO
- N2-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine
- Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K
- N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine
- 1,3,5-Triazine-2,4-diamine, N2-[4-(1H-benzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)-
- CS-2857
- AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01
- Autophagy inhibitor IITZ-01
- AUTOPHAGY INHIBITOR;IITZ 01;IITZ01
- IITZ-01