CS-2124
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- CAS號(hào):
- 1395048-49-3
- 英文名:
- 2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
- 英文別名:
- M-110;CS-2124;M 110,M110;M-110 >=98% (HPLC);M-110, 10 mM in DMSO;2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide;4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
- 中文名:
- CS-2124
- 中文別名:
- 化合物M-110;化合物 T15830;PIM激酶抑制劑(M-110);化合物M-110,10 MM DMSO 溶液
- CBNumber:
- CB02750705
- 分子式:
- C22H28ClN5O3
- 分子量:
- 445.94
- MOL File:
- 1395048-49-3.mol
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CS-2124化學(xué)性質(zhì)
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密度:
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1.31±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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2-8°C
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溶解度:
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DMSO: soluble25mg/mL, clear
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酸度系數(shù)(pKa):
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7.46±0.40(Predicted)
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形態(tài):
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powder
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顏色:
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white to beige
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CS-2124性質(zhì)、用途與生產(chǎn)工藝
M-110 是一種高選擇性的，ATP 競爭性的 PIM 激酶抑制劑，M-110 對(duì) PIM-3 抑制作用最好，IC50=47 nM。M-110 抑制 PIM-1 和 PIM-2 的IC50 為 2.5 μM。M-110 抑制前列腺癌細(xì)胞的增殖，IC50 為 0.6-0.9 μM。
M-110 (0.01-10 μM; 72 hours) inhibiting the growth of DU-145 cells with an IC
50
value of 0.9 μM. M-110 has no activity on normal human peripheral blood mononuclear cells up to 40 μM.
M-110 (10 μM; 18 hours) inhibits STAT3 Tyr705?phosphorylation.
M-110 inhibits the expression of active STAT3 through inhibition of PIM-3. M-110 also inhibits the proliferation of 22Rv1, PC3, and SW480 cells, with IC50?values of 0.6 to 0.8 μM.
Cell Viability Assay
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Cell Line:
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DU-145 cells
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Concentration:
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0.01, 0.1, 1, 10 μM
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Incubation Time:
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72 hours
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Result:
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Inhibiting the growth of DU-145 cells with an IC
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value of 0.9 μM.
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Western Blot Analysis
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Cell Line:
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DU-145 cells
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Concentration:
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10 μM
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Incubation Time:
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18 hours
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Result:
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Reduced the expression of p-STAT3 Tyr705?to 23.5%, compared with untreated cells without affecting the expression of STAT3.
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CS-2124
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2025/05/22 | HY-12830 | M-110 | 1395048-49-3 | 1 mg | 480元 |
| 2025/05/22 | HY-12830 | CS-2124
M-110 | 1395048-49-3 | 5mg | 1200元 |
1395048-49-3, CS-2124 相關(guān)搜索:
- 抑制劑
- 細(xì)胞生物學(xué)試劑
- PIM激酶抑制劑(M-110)
- 化合物M-110,10 MM DMSO 溶液
- 化合物M-110
- 化合物 T15830
- 1395048-49-3
- M-110, 10 mM in DMSO
- M 110,M110
- M-110 >=98% (HPLC)
- 4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
- CS-2124
- M-110
- 2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide