99009-20-8
中文名稱
NSC 366140 無結(jié)構(gòu)圖
英文名稱
NSC 366140
CAS
99009-20-8
分子式
C19H21N5O3
分子量
367.4
MOL 文件
99009-20-8.mol
更新日期
2023/03/20 15:41:25
99009-20-8 結(jié)構(gòu)式
基本信息
中文別名
NSC 366140 無結(jié)構(gòu)圖 英文別名
Pd 115934NSC 366140
Pd 115,934
Brn 4211902
Pyrazoloacridine
N,N-Dimethyl-9-methoxy-5-nitropyrazolo(3,4,5-kl)acridine-2(6H)-propanamine
Pyrazolo(3,4,5-kl)acridine-2(6H)-propanamine, N,N-dimethyl-9-methoxy-5-nitro-
9-Methoxy-N,N-dimethyl-5-nitropyrazolo[3,4,5-kl]acridine-2(6H)-propane-1-amine
(3-(9-METHOXY-5-NITRO-6H-PYRAZOLO(3,4,5-KL)ACRIDIN-2-YL)-PROPYL)-DIMETHYL-AMINE
2,6-Dihydro-2-(3-dimethylaminopropyl)-9-methoxy-5-nitropyrazolo[3,4,5-kl]acridine
物理化學(xué)性質(zhì)
沸點584.3±50.0 °C(Predicted)
密度1.38±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
酸度系數(shù)(pKa)9.35±0.28(Predicted)
形態(tài)Solid
顏色Light brown to orange
NSC 366140 無結(jié)構(gòu)圖價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | HY-108969 | NSC 366140 無結(jié)構(gòu)圖 Pyrazoloacridine | 99009-20-8 | 1 mg | 466元 |
| 2025/05/22 | HY-108969 | NSC 366140 無結(jié)構(gòu)圖 Pyrazoloacridine | 99009-20-8 | 10 mM * 1 mLin DMSO | 727元 |
| 2025/05/22 | HY-108969 | NSC 366140 無結(jié)構(gòu)圖 Pyrazoloacridine | 99009-20-8 | 5mg | 900元 |
常見問題列表
生物活性
Pyrazoloacridine (NSC 366140) 具有抗癌活性，抑制拓撲異構(gòu)酶 1 和 2 的活性 (topoisomerases 1 and 2)。Pyrazoloacridine (NSC 366140) 對 K562 髓系白血病細胞中的 IC50 值為 1.25 μM (24 h)。體外研究
Pyrazoloacridine (NSC 366140, PD 115934) exhibits IC
50
values of 10.7 μM and 4.5 μM for oxic and hypoxic HCT-8 cells.
Pyrazoloacridine (NSC 366140, 2-4 μM) abolishes the catalytic activity of both topo I and topo II in vitro.
Pyrazoloacridine (NSC 366140) displays activity against cisplatin- and paclitaxel-resistant ovarian cancer.
Pyrazoloacridine (NSC 366140) has been shown to cause delayed DNA fragmentation in MCF-7 breast cancer cells.
Pyrazoloacridine (NSC 366140) induces
apoptosis
in P53-deficient Hep 3B human hepatoma cells.
Cell Cytotoxicity Assay
| Cell Line: | K562 Myeloid Leukemia Cells. |
| Concentration: | 0-500 μM. |
| Incubation Time: | 1 h or 24 h. |
| Result: | When K562 cells were incubated with PA for 1 h and then plated in soft agar, an IC 50 of -50 μM was observed. In contrast, when cells were incubated for 24 h with PA, the IC 50 was 1.25 μM. |