98977-34-5
98977-34-5 結(jié)構(gòu)式
基本信息
1-BOC-4-氧-3-哌啶羧酸乙酯
N-BOC-3-乙氧羰基-4-哌啶酮
N-BOC-4-哌啶酮-3-羧酸乙酯
1-BOC-4-氧-3-哌啶甲酸乙酯
1-BOC-4-氧代-3-哌啶羧酸乙酯
1-BOC-4-氧代-3-哌啶甲酸乙酯
N-BOC-4-氧代哌啶-3-甲酸乙酯
N-BOC-4-氧代-3-哌啶甲酸乙酯
1-叔丁氧羰基-4-氧-3-哌啶羧酸乙酯
4-oxopiperidine-1,3-dicarboxyL
N-Boc-3-Carboethxy-4-Piperidone
N-BOC-3-CARBETHOXY-4-PIPERIDONE
N-BOC-3-CARBOETHOXY-4-PIPERIDONE
N-T-BOC-3-CARBOETHOXY-4-PIPERIDONE
N-BOC-3-CARBOETHOXY-4-PIPERIDONE-C
1-Boc-3-ethoxycarbonyl-4-piperidone
Ethyl 1-Boc-4-piperidone-3-carboxylate
4-Oxo-piperidine-1,3-dicarboxylic acid
物理化學(xué)性質(zhì)
制備方法
24424-99-5
1454-53-1
98977-34-5
以1-芐基-4-氧代-3-哌啶甲酸乙酯鹽酸鹽（10.0 g, 33.6 mmol）和乙醇（800 mL）為反應(yīng)體系，加入Pd/C催化劑（1.0 g, 10% w/w），在室溫下進(jìn)行氫化反應(yīng)約15小時(shí)。反應(yīng)完成后，向體系中加入三乙胺（19 mL, 134.3 mmol）和二碳酸二叔丁酯（8.0 g, 36.9 mmol），繼續(xù)在室溫下攪拌16小時(shí)。反應(yīng)混合物通過(guò)硅藻土過(guò)濾以去除催化劑，濾液經(jīng)真空濃縮后，將殘余物溶解于二氯甲烷中，用水洗滌進(jìn)行萃取。分離有機(jī)相，用無(wú)水硫酸鈉干燥，再次真空濃縮，最終得到1-N-Boc-4-氧代-3-哌啶羧酸乙酯（化合物IB，9.11 g，收率100%）。
參考文獻(xiàn)：
[1] Patent: WO2008/130584, 2008, A1. Location in patent: Page/Page column 131; 135
[2] Organic Process Research and Development, 2011, vol. 15, # 5, p. 1138 - 1148
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 13, p. 3970 - 3975
[4] Patent: WO2011/103091, 2011, A1. Location in patent: Page/Page column 93
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/05/22 | E0983 | 1-叔丁氧羰基-4-氧-3-哌啶甲酸乙酯 Ethyl 1-tert-Butoxycarbonyl-4-oxo-3-piperidinecarboxylate | 98977-34-5 | 1g | 40元 |
| 2025/05/22 | XW989773452 | 1-N-BOC-4-氧代-3-哌啶羧酸乙酯 ethyl 1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate;1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylic acid ethyl ester;ethyl 1-boc-4-oxo-3-piperidinecarboxylate;1-tert-butoxycarbonyl-3-ethoxycarbonyl-4-piperidone;1-boc-3-ethoxycarbonyl-4-piperidone;n-boc-3-carboethoxy-4-piperidone;1-boc-4-oxo-3-piperidinecarboxylic acid ethyl ester;ethyl n-boc-4-oxopiperidine-3-carboxylate;1-n-boc-4-oxo-3-piperidinecarboxylic acid ethyl ester;4-oxo-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester | 98977-34-5 | 5G | 53元 |
| 2025/05/22 | E0983 | 1-叔丁氧羰基-4-氧-3-哌啶甲酸乙酯 Ethyl 1-tert-Butoxycarbonyl-4-oxo-3-piperidinecarboxylate | 98977-34-5 | 5g | 180元 |