931078-17-0
中文名稱
1,4-Benzodioxin-6-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-2,3-dihydro-8-methoxy-
英文名稱
1,4-Benzodioxin-6-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-2,3-dihydro-8-methoxy-
CAS
931078-17-0
分子式
C18H20N2O5
分子量
344.36
MOL 文件
931078-17-0.mol
931078-17-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T27074 英文別名
CPI905CPI-905
CPI 905
1,4-Benzodioxin-6-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-2,3-dihydro-8-methoxy-
物理化學(xué)性質(zhì)
沸點(diǎn)548.8±50.0 °C(Predicted)
密度1.237±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)11.89±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
CPI-905 is a potent and selective EZH2 inhibitor (IC50 = 39.5 nM). The histone lysine methyltransferase (MT) Enhancer of Zeste Homolog 2 (EZH2) is considered an oncogenic driver in a subset of germinal center B-celllike diffuse large B cell lymphoma (GCB-DLBCL) and follicular lymphoma due to the presence of recurrent, monoallelic mutations in the EZH2 catalytic domain. .