776-53-4
776-53-4 結(jié)構(gòu)式
基本信息
2-甲硫基-4-氨基-5-嘧啶甲酸乙酯
2-甲硫基-4-氨基嘧啶-5-羧酸乙酯
2-甲基巰基-4-氨基嘧啶-5-羧酸乙酯
2-甲基巰基-4-氨基嘧啶-5-甲酸乙酯
4-氨基-2- 甲硫基嘧啶-5- 甲酯乙酯
2-(甲硫基)-4-氨基嘧啶-5-甲酸乙酯
4-氨基-2-(甲巰基)嘧啶-5-甲酸乙酯
2-甲硫基-4-氨基-5-嘧啶甲酸乙酯 1G
4-氨基-2-(甲基硫代)-5-嘧啶甲酸乙酯
4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CA...
hyl 4-aMino-2-(Methylthio)pyriMidine-5-carboxylate
Ethyl 4-amino-2-(methylthio)pyrimidin-5-carboxylate
thyl 4-aMino-2-(Methylthio)pyriMidine-5-carboxylate
Ethyl 4-aMino-2-(Methylthio)-5-pyriMidinecarboxylate
ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE
ethyl 4-amino-2-methylsulfanyl-pyrimidine-5-carboxylate
ETHYL-4-AMINO-2-METHYL MERCAPTO-PYRIMIDINE-4-CARBOXYLATE
ethyl 4-azanyl-2-methylsulfanyl-pyrimidine-5-carboxylate
物理化學(xué)性質(zhì)
制備方法
5909-24-0
776-53-4
步驟1. 在2L三頸燒瓶中依次加入4-氯-2-(甲硫基)嘧啶-5-羧酸乙酯(100g, 0.43mol)、四氫呋喃(THF, 500mL)和三乙胺(TEA, 186mL, 1.29mol)。在攪拌下分批加入28%氫氧化銨水溶液(400mL)，控制反應(yīng)溫度低于30℃。反應(yīng)2小時后，加入水(1000mL)，通過真空蒸餾除去THF。將反應(yīng)混合物過濾，收集固體產(chǎn)物，并在50℃下真空干燥，得到白色固體4-氨基-2-(甲硫基)嘧啶-5-羧酸乙酯(90g, 收率99%)。產(chǎn)物經(jīng)LC/MS分析顯示m/z = 213.9 [M+H]+；1H-NMR (DMSO-d6, 400MHz) δ 8.57 (s, 1H), 8.03 (br, 1H), 7.65 (br, 1H), 4.27 (q, J = 7.5Hz, 2H), 2.46 (s, 3H), 1.29 (t, J = 7.2Hz, 3H)。
參考文獻：
[1] Patent: US2015/31674, 2015, A1. Location in patent: Paragraph 0319
[2] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 12, p. 1241 - 1246
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 11, p. 5520 - 5541
[4] Patent: WO2014/182829, 2014, A1. Location in patent: Page/Page column 42
[5] Patent: WO2015/120049, 2015, A1. Location in patent: Page/Page column 126; 127