763111-47-3
763111-47-3 結(jié)構(gòu)式
基本信息
4-(4-氟-3-(哌嗪-1-羰基)芐基)酞嗪-1(2H)-酮
4-[4-氟-3-(哌嗪-1-羰基)芐基]-2H-酞 嗪-1-酮
4 - [[4-氟-3-(哌嗪-1-羰基)苯基]甲基]-2H-酞嗪-1-酮
1-[5-[(3,4-二氫-4-氧代-1-酞嗪基)甲基]-2-氟苯甲?；鵠哌嗪
Olaparib Descyclopropanecarbonyl Impurity
4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one
4-[4-Fluoro-3-(1-piperazinylcarbonyl)benzyl]-1(2H)-phthalazinone
4-[4'-fluoro-3'-(piperazine-1''-carbonyl)benzyl]-2H-phthalazin-1-one
4-[[4-fluoro-3-(piperazine-1-carbonyl)phenyl]Methyl]-2H-phthalazin-1-one
1(2H)-Phthalazinone, 4-[[4-fluoro-3-(1-piperazinylcarbonyl)phenyl]methyl]-
1-[5-[(3,4-Dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine
物理化學性質(zhì)
制備方法
763114-04-1
763111-47-3
以4-(2-氟-5-((4-氧代-3,4-二氫酞嗪-1-基)甲基)苯甲酰基)哌嗪-1-羧酸叔丁酯為原料，合成4-(4-氟-3-(哌嗪-1-羰基)芐基)酞嗪-1(2H)-酮的一般步驟如下：在室溫條件下，將原料（13.6g，29mmol）溶解于30ml乙醇中，緩慢加入6ml濃鹽酸（60ml），持續(xù)攪拌反應(yīng)3小時。反應(yīng)完成后，將反應(yīng)液濃縮至約50ml。用4N的NH4OH溶液調(diào)節(jié)pH至10。隨后，用二氯甲烷（3×50ml）萃取反應(yīng)混合物，合并有機相并用50ml水洗滌。有機相加入無水硫酸鈉干燥30分鐘。干燥后，過濾除去硫酸鈉，濾液靜置過夜以析出產(chǎn)物。最后，過濾收集白色固體產(chǎn)物4-(4-氟-3-(哌嗪-1-羰基)芐基)酞嗪-1(2H)-酮（9.9g，收率92%）。
參考文獻：
[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 20, p. 6581 - 6591
[2] Patent: CN106946792, 2017, A. Location in patent: Paragraph 0074; 0081-0084
[3] Patent: CN106928149, 2017, A. Location in patent: Paragraph 0006; 0015; 0028; 0036; 0044-0046
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 21, p. 8683 - 8693
[5] Patent: WO2008/47082, 2008, A2. Location in patent: Page/Page column 22
常見問題列表
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | HY-75706 | 1-[5-[(3,4-二氫-4-氧代-1-酞嗪基)甲基]-2-氟苯甲?；鵠哌嗪 N-Descyclopropanecarbaldehyde Olaparib | 763111-47-3 | 100 mg | 100元 |
| 2025/05/22 | HY-75706 | 1-[5-[(3,4-二氫-4-氧代-1-酞嗪基)甲基]-2-氟苯甲?；鵠哌嗪 N-Descyclopropanecarbaldehyde Olaparib | 763111-47-3 | 10 mM * 1 mLin DMSO | 110元 |
| 2025/05/22 | HY-75706 | 1-[5-[(3,4-二氫-4-氧代-1-酞嗪基)甲基]-2-氟苯甲?；鵠哌嗪 N-Descyclopropanecarbaldehyde Olaparib | 763111-47-3 | 250mg | 200元 |