740790-94-7
中文名稱
UUKPXXBDUCDZDA-KAFVXXCXSA-N
英文名稱
UUKPXXBDUCDZDA-KAFVXXCXSA-N
CAS
740790-94-7
分子式
C10H15FN3O15P3
分子量
529.157
MOL 文件
740790-94-7.mol
740790-94-7 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
熔點(diǎn)>123°C (dec.)
儲(chǔ)存條件Hygroscopic, -86°C Freezer, Under inert atmosphere
溶解度可微溶于水
形態(tài)固體
顏色淺黃色至淺綠色
常見問題列表
生物活性
T-705RTP 是一種具有具有選擇性和 GTP 競(jìng)爭(zhēng)性的流感病毒 RNA 聚合酶 (RNA polymerase) 抑制劑，IC50 為 0.14 μM，Ki 為 1.52 μM。T-705RTP 是 T-705 的活性三磷酸鹽代謝產(chǎn)物，具有有效的抗流感病毒活性。靶點(diǎn)
IC50: 0.14 μM (Influenza virus RNA polymerase)
Ki: 1.52 μM (Influenza virus RNA polymerase)
體外研究
T-705RTP and T-705RMP are detected in MDCK cells treated with T-705. T-705RTP inhibits influenza virus RNA polymerase activity in a dose-dependent and a GTP-competitive manner.
T-705RTP inhibits the incorporation of ATP and GTP in a competitive manner with K
i
values of 7.72 and 1.56 μM, respectively. T-705RTP inhibits the incorporation of CTP in a mixed-type manner with a K
i
value of 11.3 μM, and also inhibits the incorporation of UTP in a noncompetitive manner.
The incorporation of a single molecule of T-705RTP (10-1000 μM) inhibits influenza virus RNA strand extension.