73842-99-6
73842-99-6 結(jié)構(gòu)式
基本信息
3-(叔丁基二甲基硅氧基)丙醇
3-[(叔丁基二甲基硅烷基)氧基]丙醇
3-((叔丁基二甲基甲硅烷基)氧)丙醇
3-(叔丁基二甲基硅氧基)丙醇 25G
3-((輸丁基二甲基甲硅烷基)氧)-丙醇
3-(T-BUTYLDIMETHYLSILOXY)PROPANOL
3-(T-Butyldimethylsiloxy)propan-1-ol
3-(TERT-BUTYLDIMETHYLSILOXY)PROPANOL
3-[(TERT-BUTYLDIMETHYLSILYL)OXY]PROPANOL
3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANOL
3-(tert-ButyldiMethylsilanyloxy)propan-1-ol
3-((tert-ButyldiMethylsilyl)oxy)propan-1-ol
3-((tert-ButyldiMethylsilyl)oxy)-propanol 97%
3-[Dimethyl(1,1-dimethylethyl)siloxy]propanol
物理化學(xué)性質(zhì)
制備方法
18162-48-6
504-63-2
73842-99-6
以叔丁基二甲基氯硅烷和1,3-丙二醇為原料合成3-(叔丁基二甲基硅氧基)丙醇的一般步驟如下：該合成作為制備dictyostatin及其類似物的示例性“底部片段”15的一部分，已在文獻(xiàn)中報(bào)道。具體而言，1,3-丙二醇經(jīng)過基于Evans手性輔助的方法，經(jīng)過九個(gè)步驟轉(zhuǎn)化為已知的雙-TBS保護(hù)的Homer-Wadsworth-Emmons產(chǎn)物10。相關(guān)文獻(xiàn)參見：Phukan, P.; Sasmal, S.; Maier, M. E. Eur. J. Org. Chem. 2003, 1733以及Andrus, M. B.; Argade, A. B. Tetrahedron Lett. 1996, 37, 5049。
參考文獻(xiàn)：
[1] Patent: WO2005/117588, 2005, A2. Location in patent: Page/Page column 31
[2] Journal of the American Chemical Society, 2004, vol. 126, # 37, p. 11440 - 11441
[3] Organic Letters, 2007, vol. 9, # 16, p. 3105 - 3108
[4] Patent: WO2014/145302, 2014, A2. Location in patent: Page/Page column 34; 35; 38; 39
[5] Patent: WO2016/44558, 2016, A1. Location in patent: Page/Page column 51; 52; 54; 55