7326-73-0

基本信息
N,N-二甲基- 3-羧基苯磺酰胺
3-(N,N-DiMethylsulfaMoyl)benzoic acid
3-(N,N-Dimethylsulphamoyl)benzoic acid
3-[(Dimethylamino)sulphonyl]benzoic acid
Benzoic acid, 3-[(diMethylaMino)sulfonyl]-
3-[(dimethylamino)sulfonyl]benzenecarboxylic acid
3-[(Dimethylamino)sulphonyl]benzoic acid, 3-Carboxy-N,N-dimethylbenzenesulphonamide
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
4025-64-3

124-40-3

7326-73-0
以3-氯磺酰基苯甲酸和二甲胺為原料合成N,N-二甲基-3-羧基苯磺酰胺的一般步驟如下:將3-氯磺?;郊姿幔?.60 g,12 mmol)溶解于二氯甲烷(DCM,20 mL)中,隨后加入二甲胺(2.0 M在四氫呋喃(THF)中,20 mL,40 mmol,3.3當(dāng)量)。反應(yīng)混合物在室溫下攪拌30分鐘后,用10%鹽酸(HCl)溶液淬滅反應(yīng)。反應(yīng)混合物用乙酸乙酯(EtOAc)萃取,有機(jī)相用飽和氯化鈉(NaCl)溶液洗滌,并用無(wú)水硫酸鈉(Na2SO4)干燥。最后,通過(guò)減壓蒸餾除去有機(jī)溶劑,得到目標(biāo)產(chǎn)物N,N-二甲基-3-羧基苯磺酰胺(1.80 g,產(chǎn)率65%);質(zhì)譜(m/z)229。
參考文獻(xiàn):
[1] ChemMedChem, 2015, vol. 10, # 9, p. 1548 - 1558
[2] Patent: WO2006/24834, 2006, A1. Location in patent: Page/Page column 82
[3] Patent: WO2006/24836, 2006, A1. Location in patent: Page/Page column 30
[4] Patent: WO2007/71963, 2007, A2. Location in patent: Page/Page column 50
[5] Patent: WO2006/40568, 2006, A1. Location in patent: Page/Page column 82