58012-34-3

基本信息
4-羰基環(huán)己烷乙酸乙酯
乙烷基-4含氧環(huán)己烷醋酸鹽
2-(4-氧代環(huán)己基)乙酸乙酯
ethyl 2-(4-oxocyclohexyl)acetate
ethyl 4-oxocyclohexaneacetate-26
Ethyl (4-oxocyclohex-1-yl)acetate
Ethyl (4-oxocyclohex-1-yl)acetate 95%
4-Oxocyclohexaneacetic acid ethyl ester
2-(4-Oxocyclohexyl)acetic Acid Ethyl Ester
Ethyl 2-(4-Oxocyclohexyl)Acetate(WXC03040)
(4-Oxo-cyclohexyl)-acetic acid ethyl ester
(4-Oxocyclohex-1-yl)acetic acid ethyl ester, Ethyl 2-(4-oxocyclohex-1-yl)ethanoate
物理化學性質
制備方法
![(1,4-二氧雜-螺[4.5]癸-8-基)-乙酸 乙基 酯](/StructureFile/ChemBookStructure9/GIF/CB7769179.gif)
62141-26-8

58012-34-3
向丙酮(720 mL)中加入10 g(43.8 mmol,1當量)的(1,4-二氧雜螺[4.5]癸-8-基)乙酸乙酯,隨后加入1 N鹽酸(180 mL)。將反應混合物加熱回流2小時。反應完成后,冷卻至室溫,用乙酸乙酯(100 mL)稀釋,并用去離子水(100 mL)洗滌。水層用乙酸乙酯(100 mL)反萃取兩次,合并所有有機層,用無水硫酸鎂干燥,過濾,減壓濃縮,得到7.57 g(產率94%)的4-氧代環(huán)己烷乙酸乙酯,為透明油狀物。產物經1H-NMR(CDCl3)表征:δ 4.16(q,2H),2.40(m,4H),2.32(m,2H),2.28(m,1H),2.10(m,2H),1.49(m,2H),1.28(t,3H);TLC Rf = 0.32(展開劑比例為3:7的乙酸乙酯/正己烷)。
參考文獻:
[1] Patent: WO2005/10008, 2005, A1. Location in patent: Page/Page column 105-106
[2] Angewandte Chemie - International Edition, 2010, vol. 49, # 33, p. 5693 - 5697
[3] Patent: WO2006/44524, 2006, A1. Location in patent: Page/Page column 46-47
[4] Angewandte Chemie - International Edition, 2007, vol. 46, # 33, p. 6278 - 6283
[5] Tetrahedron, 1995, vol. 51, # 37, p. 10259 - 10280