537034-15-4
中文名稱(chēng)
PAOA
英文名稱(chēng)
N-(2-Aminophenyl)-N'-phenylheptanediamide
CAS
537034-15-4
分子式
C19H23N3O2
分子量
325.4
MOL 文件
537034-15-4.mol
更新日期
2025/08/13 14:38:04
537034-15-4 結(jié)構(gòu)式
基本信息
中文別名
化合物PAOAHDAC抑制劑(NKL 22)
英文別名
NKL 22HDACi-4b
MDK-4154
NKL22, >98%
NKL 22, >98%
HDAC inhibitor IV
Histone Deacetylase Inhibitor IV
N-(2-Aminophenyl)-N'-phenylheptanediamide
N1-(2-AMinophenyl)-N7-phenylheptanediaMide
Heptanediamide, N1-(2-aminophenyl)-N7-phenyl-
所屬類(lèi)別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
熔點(diǎn)159-161°C
沸點(diǎn)627.9±40.0 °C(Predicted)
密度1.212±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C冷凍
溶解度可溶于二甲基亞砜、甲醇
酸度系數(shù)(pKa)14?+-.0.70(Predicted)
形態(tài)米色固體
顏色灰白色至淺米色
應(yīng)用領(lǐng)域
用途1
Histone deacetylase inhibitor IV. A cell-permeable pimeloylanilide compound that acts as a FXN-(frataxin gene) specific HDAC inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedrich鈥檚
ataxia) cells due to hypoacetylation of histones H3 and H4.