501945-71-7
501945-71-7 結(jié)構(gòu)式
基本信息
苯并[B]噻吩-5-硼酸頻哪醇酯
2-(1-苯并噻吩-5-基)-4
2-(1-苯并噻吩-5-基)-4,4,5,5-四甲基-1,3,2-二氧硼烷
2-(苯并[B]噻吩-5-基)-4,4,5-5-四甲基-1,3,2-二氧雜硼烷
2-(1-benzothiophen-5-yl)-4
Benzo[b]thiophene-5-boronic Acid Pinacol Ester
2-(benzothiophen-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
2-(1-BENZOTHIOPHEN-5-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE
2-(benzo[b]thiophen-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Benzo[b]thiophene, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
2-(1-Benzothiophen-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ,95%
制備方法
![5-溴苯并[b]噻吩](/CAS/GIF/4923-87-9.gif)
4923-87-9
73183-34-3
501945-71-7
將5-溴苯并[b]噻吩（49 g，7.0 mmol）溶于DMSO（40 mL）中。向該溶液中依次加入雙（頻哪醇合）二硼（7 mmol）、PdCl2(dppf)-CH2Cl2（0.33 mmol）和KOAc（20 mmol）。用氮氣對反應(yīng)體系進(jìn)行置換后，將反應(yīng)混合物在攪拌下加熱至80℃。維持該溫度反應(yīng)3小時后，將反應(yīng)混合物冷卻至室溫。向反應(yīng)混合物中加入水（66 mL），隨后用EtOAc（3×66 mL）萃取水層。合并有機(jī)層，用無水Na2SO4干燥，過濾后濃縮。最后，通過快速柱色譜法（硅膠，0-5% Et2O/戊烷為洗脫劑）純化，得到2-(1-苯并噻吩-5-基)-4,4,5,5-四甲基-1,3,2-二氧硼烷1.56 g，收率86%。
參考文獻(xiàn)：
[1] Patent: WO2004/9086, 2004, A1. Location in patent: Page/Page column 49
[2] Patent: US2006/52378, 2006, A1. Location in patent: Page/Page column 104
[3] Journal of the American Chemical Society, 2017, vol. 139, # 24, p. 8267 - 8276
[4] Angewandte Chemie - International Edition, 2018, vol. 57, # 34, p. 10999 - 11003
[5] Angew. Chem., 2018, # 130, p. 11165 - 11169,5
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | XW0250194571704 | 2-(1-苯并噻吩-5-基)-4,4,5,5-四甲基-1,3,2-二氧硼烷 | 501945-71-7 | 5G | 1141元 |
| 2025/05/22 | XW0250194571703 | 2-(1-苯并噻吩-5-基)-4,4,5,5-四甲基-1,3,2-二氧硼烷 | 501945-71-7 | 1G | 332元 |
| 2025/05/22 | XW0250194571702 | 2-(1-苯并噻吩-5-基)-4,4,5,5-四甲基-1,3,2-二氧硼烷 | 501945-71-7 | 250MG | 124元 |