4673-26-1
4673-26-1 結構式
基本信息
二亞苯基碘氯化物
氯化二亞苯基碘嗡
氯化二亞苯基碘鎓
二亞苯基碘鎓氯化物
DPI CHLORIDE
DIBENZIODOLIUM CHLORIDE
DIPHENYLENEIODONIUM CHLORIDE
Dibenz[b,d]iodoliuM Chloride
Dibenziodolium chloride, DPI
Diphenyleneiodonium chloride, 97+%
DiphenyleneiodoniuM chloride, 97+% 25MG
[1,1'-BIPHENYL]-2,2'-DIYLIODONIUM CHLORIDE
Diphenyleneiodonium chlorideDibenziodolium chloride
物理化學性質
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | 32866 | 二苯基氯化碘鹽 Diphenyleneiodonium chloride, 97+%, Thermo Scientific Chemicals | 4673-26-1 | 25mg | 2646元 |
| 2025/05/22 | HY-100965 | 二苯基氯化碘鹽 Diphenyleneiodonium chloride | 4673-26-1 | 5 mg | 481元 |
| 2025/05/22 | HY-100965 | 二苯基氯化碘鹽 Diphenyleneiodonium chloride | 4673-26-1 | 10mg | 770元 |
常見問題列表
| Target | Value |
|
NADPH oxidase
() |
DPI抑制NADPH oxidase、一氧化氮合成酶、黃嘌呤氧化酶和NADPH細胞色素P450氧化還原酶的活性。飛摩爾級別的DPI即可通過抑制ERK調節(jié)的PHOX活性、抑制小膠質細胞的激活，發(fā)揮其抗炎活性和神經(jīng)保護作用。DPI常被用于抑制由多種黃素酶介導的ROS生成。NADPH, NADP+, and 2'5'-ADP可阻止DPI的抑制活性。對ARPE-19細胞處理以DPI可引起劑量依賴性和時間依賴性的生長抑制，誘導DNA斷裂和促凋亡因子Bax的蛋白水平。除此之外，DPI還可顯著地誘導p53的表達和其磷酸化，在DNA損傷或無法修復的DNA周期阻滯中，誘導促凋亡基因的表達。
Intraplantar injection of 2 mM Diphenyleneiodonium chloride to the hindpaw causes licking or biting behavior. Diphenyleneiodonium chloride treatment immediately or 24 h after lipopolysaccharide (LPS) injection significantly attenuates the LPS-induced loss of O4 positive cells. Treatment with Diphenyleneiodonium chloride either immediately or 24 h after LPS injection significantly ameliorates the LPS-induced disorganization of the white matter nerve fibers. However, treatment with DPI 48 h after LPS injection does not appear to correct the LPS-induced white matter damage. DPI treatment either immediately or 24 h after LPS injection significantly reduces the accumulation of both gp91phox and p67phox in the membrane fraction.