4303-67-7
4303-67-7 結(jié)構(gòu)式
基本信息
N-十二烷基咪唑
1-十二烷基咪唑
N-正十二烷基咪唑
1-十二烷基咪唑 25G
(3R,4S)-1-芐基-N,4-二甲基哌啶-3-胺
n-laurylimidazole
1-laurylimidazole
1-dodecliMidazole
N-DODECYLIMIDAZOLE
1-DODECYLIMIDAZOLE
1-dodecyl-imidazol
1-dodecyl-1h-imidazol
1-Dodecylimidazole,97%
1-Dodecylimidazole,95%
物理化學性質(zhì)
制備方法
288-32-4
143-15-7
4303-67-7
以咪唑（0.68 g，10 mmol）和溴代十二烷（2.5 g，10 mmol）為原料，加入無水碳酸鉀（2.76 g，20 mmol）于50 mL圓底燒瓶中，溶解于20 mL丙酮中。將混合溶液加熱回流7小時。反應完成后，通過旋轉(zhuǎn)蒸發(fā)去除丙酮溶劑。粗產(chǎn)物經(jīng)柱層析純化，使用乙酸乙酯作為洗脫液。收集目標組分后，通過減壓旋轉(zhuǎn)蒸發(fā)除去乙酸乙酯溶劑，最終產(chǎn)物經(jīng)真空干燥，得到純化的1-十二烷基咪唑，產(chǎn)率為90%。
參考文獻：
[1] Russian Journal of Organic Chemistry, 2013, vol. 49, # 9, p. 1291 - 1299
[2] Zh. Org. Khim., 2013, vol. 49, # 9, p. 1308 - 1316,9
[3] Patent: CN106188014, 2016, A. Location in patent: Paragraph 0016
[4] Patent: CN103951702, 2016, B. Location in patent: Paragraph 0059; 0060
[5] Tetrahedron, 2010, vol. 66, # 35, p. 7077 - 7082
常見問題列表
N-dodecylimidazole, an acid activated detergent with a pKa of 6.3, has been shown to be cytotoxic to cells in culture. N-dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose dependent and was 100-fold greater at pHe 6.0 than pHe 7.0.
The hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase.
1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) has lower serum cholesterol concentrations than control rats.
| Animal Model: | Male rats |
| Dosage: | 150 mg/kg body wt |
| Administration: | By stomach tube; daily for 10 days |
| Result: | Had significantly lower serum cholesterol concentrations than untreated animals. |