42058-59-3
42058-59-3 結(jié)構(gòu)式
基本信息
3-羥基苯乙酸甲酯
3-羥基苯基乙酸甲酯
2-(3-羥基苯基)乙酸甲酯
Methyl m-hydroxyphenylacetate
METHYL 3-HYDROXYPHENYL ACETATE
Methyl 3-hydroxybenzeneacetate
Methyl 2-(3-hydroxyphenyl)acetate
3-HYDROXYPHENYLACETIC ACID METHYL ESTER
2-(3-Hydroxyphenyl)acetic acid methyl ester
Benzeneacetic acid, 3-hydroxy-, methyl ester
物理化學(xué)性質(zhì)
制備方法
67-56-1
621-37-4
42058-59-3
步驟1: 將3-羥基苯基乙酸(15.2 g, 0.1 mol, 1.0當(dāng)量)和濃硫酸(392 mg, 4 mmol, 0.04當(dāng)量)溶解于甲醇(100 mL)中。將反應(yīng)混合物在室溫下攪拌1小時(shí)，隨后用氫氧化鈉溶液淬滅反應(yīng)。用乙酸乙酯萃取反應(yīng)混合物，有機(jī)層用無水硫酸鈉干燥后，減壓濃縮。通過硅膠柱色譜法(洗脫劑:石油醚/乙酸乙酯=5:1)純化粗產(chǎn)物，得到2-(3-羥基苯基)乙酸甲酯，為黃色油狀物(14.2 g, 產(chǎn)率86%)。1H NMR (400 MHz, CDCl3) δ= 7.15-7.19 (m, 1H), 6.81 (d, 1H), 6.72-6.76 (m, 2H), 5.88 (s, 1H), 3.70 (s, 3H), 3.58 (s, 2H); LCMS m/z 167 [M + 1]+。
參考文獻(xiàn)：
[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 21, p. 5488 - 5492
[2] Patent: WO2004/63155, 2004, A1. Location in patent: Page 58
[3] Patent: WO2005/66136, 2005, A1. Location in patent: Page/Page column 51
[4] Patent: WO2005/19190, 2005, A2. Location in patent: Page/Page column 51
[5] Patent: WO2005/103050, 2005, A2. Location in patent: Page/Page column 168