39111-07-4
中文名稱
NIGRANOIC ACID
英文名稱
NIGRANOIC ACID
CAS
39111-07-4
分子式
C30H46O4
分子量
470.69
MOL 文件
39111-07-4.mol
更新日期
2025/05/27 10:52:36
39111-07-4 結(jié)構(gòu)式
基本信息
中文別名
黑五味子酸 英文別名
NIGRANOIC ACID(3S,3aR,4aS,6aR,7R,9aS,9bS)-7-[(1R,4Z)-5-Carboxy-1-methyl-4-hexen-1-yl]decahydro-6a,9a-dimethyl-3-(1-methylethenyl)-1H-cyclopenta[a]cyclopropa[e]naphthalene-3a(4H)-propanoic acid
1H-Cyclopenta[a]cyclopropa[e]naphthalene-3a(4H)-propanoic acid, 7-[(1R,4Z)-5-carboxy-1-methyl-4-hexen-1-yl]decahydro-6a,9a-dimethyl-3-(1-methylethenyl)-, (3S,3aR,4aS,6aR,7R,9aS,9bS)-
所屬類別
有機(jī)原料：羧酸類化合物及衍生物物理化學(xué)性質(zhì)
熔點(diǎn)128-130 °C
沸點(diǎn)603.0±28.0 °C(Predicted)
密度1.10±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系數(shù)(pKa)4.78±0.10(Predicted)
形態(tài)粉末
顏色Off-white to light yellow
NIGRANOIC ACID價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/05/22 | HY-122935 | Nigranoic acid | 39111-07-4 | 1 mg | 1950元 |
| 2025/05/22 | HY-122935 | NIGRANOIC ACID Nigranoic acid | 39111-07-4 | 5mg | 4900元 |
常見問題列表
生物活性
Nigranoic acid 是五味子中分離得到的一種三萜類化合物。Nigranoic acid 能抑制 HIV-1 逆轉(zhuǎn)錄酶。在腦缺血再灌注動(dòng)物模型中，Nigranoic acid 通過 PARP/AIF 信號(hào)通路保護(hù)大腦。靶點(diǎn)
HIV-1 reverse transcriptase
體內(nèi)研究
Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation.
Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.
| Animal Model: | Sprague–Dawley rats (200-300 g), ischemia–reperfusion model |
| Dosage: | 1 mg/kg |
| Administration: | Intragastric; 6 hours and 2 hours before brain ischemia |
| Result: | Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points. |