38562-01-5

基本信息
二諾前列特羅莫
地諾前列素氮三丁醇
氨丁三醇地諾前列素
地諾前列素氨丁三醇
地諾前列腺素 氨丁三醇
前列腺素 F2ΑTRIS 鹽
地諾前列素氨丁三醇 EP標準品
地諾前列素氨丁三醇 USP標準品
地諾前列素氨丁三醇/前列腺素F2ΑTRIS鹽
u14585
lutalyse
PGF2αTris
Ensaprost
u-14,583e
PGF2ALPHA
Zinoprost
PGF2a-THAM
THAM PGF2α
物理化學性質(zhì)
ethanol: 50mg/mL
安全數(shù)據(jù)
制備方法

551-11-1

77-86-1

38562-01-5
以(Z)-7-((1R,2R,3R,5S)-3,5-二羥基-2-((S,E)-3-羥基-1-烯-1-基)環(huán)戊基)庚-5-烯酸(前列腺素F2α,式6)和三(羥甲基)氨基甲烷為原料合成地諾前列素氨丁三醇的一般步驟:將150g前列腺素F2α(式6)的油狀物與5L乙腈混合,加熱至完全溶解??刂品磻?yīng)溫度在43至47℃之間,攪拌15分鐘。隨后進行熱過濾,收集濾液,并用乙腈洗滌殘渣。將乙腈的總體積調(diào)整至21L,合并所有濾液,攪拌約5分鐘。在攪拌過程中,向濾液中緩慢加入由49.2g三(羥甲基)氨基甲烷和90ml水配制成的氨丁三醇溶液。將反應(yīng)混合物加熱至53~57℃,保持5分鐘以促進結(jié)晶沉淀的形成。加入結(jié)晶后,繼續(xù)攪拌反應(yīng)18~24小時。反應(yīng)完成后,讓反應(yīng)混合物自然冷卻至室溫,進行過濾。用乙腈洗滌結(jié)晶三次,每次100ml。將所得結(jié)晶置于五水磷酸鹽干燥劑中,進行真空干燥直至恒重,通常需要5小時以上。最終得到約180g地諾前列素氨丁三醇(7),產(chǎn)率為89%。
參考文獻:
[1] Patent: CN106810484, 2017, A. Location in patent: Paragraph 0025
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2025/05/22 | HY-12956A | 地諾前列素氨丁三醇 Dinoprost tromethamine salt | 38562-01-5 | 1 mg | 220元 |
2025/05/22 | HY-12956A | 地諾前列素氨丁三醇 Dinoprost tromethamine salt | 38562-01-5 | 5mg | 550元 |
2025/05/22 | HY-12956A | 地諾前列素氨丁三醇 Dinoprost tromethamine salt | 38562-01-5 | 10mM * 1mLin DMSO | 605元 |
常見問題列表
FP Receptor
|
Human Endogenous Metabolite
|
Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells.
Dinoprost tromethamine salt (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors.
Apoptosis Analysis
Cell Line: | Goat luteal cells |
Concentration: | 1 μM |
Incubation Time: | For 24 hours |
Result: | Significantly increased the apoptotic rate (15.62±3.12%). |
Cell Autophagy Assay
Cell Line: | Goat luteal cells |
Concentration: | 1 μM |
Incubation Time: | For 24 hours |
Result: | There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells. |
Western Blot Analysis
Cell Line: | Goat luteal cells |
Concentration: | 1 μM |
Incubation Time: | For 24 hours |
Result: | The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells. |