371945-06-1

基本信息
3-氨基呋喃并[2,3-B]吡啶-2-羧酸乙酯
3-氨基-呋喃并[2,3-B]嘧啶-2-甲酸乙酯
ethyl 2-aminofuro[2,3-b]pyridine-3-carboxylate
ethyl 3-amino furo[2,3-b]pyridine-2-carboxylate
Ethyl 3-aminofuro[2,3-B]pyridine-2-carboxylate ,98%
2-amino-3-furo[2,3-b]pyridinecarboxylic acid ethyl ester
3-Amino-furo[2,3-b]pyridine-2-carboxylic acid ethyl este
3-Amino-furo[2,3-b]pyridine-2-carboxylic acid ethyl ester
Furo[2,3-b]pyridine-2-carboxylicacid,3-amino-, ethyl ester
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) USP/EP/BP
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表

6602-54-6

623-50-7
![3-氨基-呋喃并[2,3-B]嘧啶-2-甲酸乙酯](/CAS/GIF/371945-06-1.gif)
371945-06-1
以2-氯-3-氰基吡啶(2.00g,1.0當(dāng)量)和乙醇酸乙酯(1.43mL,1.05當(dāng)量)為原料,在攪拌條件下,向反應(yīng)混合物中加入CuI(0.05g,0.02當(dāng)量)和Cs2CO3(10.3g,2.2當(dāng)量)。將反應(yīng)體系加熱至70°C,維持此溫度反應(yīng)4小時(shí)。反應(yīng)完成后,將混合物冷卻至室溫,緩慢倒入去離子水(300mL)中,靜置1小時(shí)以促進(jìn)沉淀形成。隨后,過(guò)濾收集沉淀,用乙醚/正己烷(1:1,v/v)混合溶劑研磨,最后通過(guò)甲苯共沸干燥,得到目標(biāo)產(chǎn)物3-氨基呋喃并[2,3-b]吡啶-2-羧酸乙酯(51c,2.0g,收率70%)。
參考文獻(xiàn):
[1] Patent: US2010/261714, 2010, A1. Location in patent: Page/Page column 75
[2] Synthesis, 2007, # 20, p. 3247 - 3251
[3] Patent: WO2017/90058, 2017, A1. Location in patent: Page/Page column 14
[4] Patent: WO2011/21038, 2011, A1. Location in patent: Page/Page column 18; 24
[5] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 2, p. 138 - 142