36421-15-5

基本信息
決奈達隆中間體2
決奈達隆中間體-氯丙烷
1-二正丁胺-3-氯丙烷
N-(3-氯丙基)二丁胺
N-(3-氯丙基)二丁基胺
N-(3-氯丙基)二正丁胺
3-氯-N,N-二丁基丙胺
1-二正丁胺-3-氯丙烷(160,000 )
決奈達隆中間體2/N-(3-氯丙基)二丁基胺
NSC51133
Einecs 253-027-7
Dronedarone Intermediate 2
Dibutyl(3-chloropropyl)aMine
N-(3-chloropropyl)dibutylamine
1-Dibutylamino-3-chloropropane
1-Chloro-3-di-N-butylaminopropane
Dronedarone Hydrochloride IMpurity F
N-(3-Chloropropyl) dibutyl amine (NCA)
物理化學(xué)性質(zhì)
常見問題列表

2050-51-3

36421-15-5
以3-(二丁基氨基)丙-1-醇為原料合成N-(3-氯丙基)二丁基胺的一般步驟:將3-(二丁基氨基)丙-1-醇(2.230 mmol,0.418 g)溶解于氯仿(5 mL)中,通過注射器緩慢加入亞硫酰氯(4.460 mmol,0.328 mL)。將反應(yīng)混合物在回流條件下攪拌7小時。反應(yīng)完成后,將反應(yīng)混合物用水和二氯甲烷稀釋,并加入碳酸鉀(1.2 g)。有機層依次用飽和碳酸氫鈉水溶液(5 mL)和水(5 mL)洗滌。有機層用無水硫酸鎂干燥,過濾后,真空除去溶劑,得到N-(3-氯丙基)二丁基胺,為黃色油狀物(0.430 g,產(chǎn)率94%)。1H NMR(400 MHz,CDCl3)δ 3.62(t,J = 6.5 Hz,1H),2.55(t,J = 6.8 Hz,1H),2.40(t,2H),1.89(qi,1H),1.48-1.36(m,2H),1.36-1.26(m,2H),0.93(t,J = 7.3 Hz,3H)。13C NMR(101 MHz,CDCl3)δ 54.02,51.06,43.45,30.61,29.43,20.67,14.05。HRMS(EI+):m/z C11H24NCl的計算值:205.1597,實測值:205.1596。
參考文獻:
[1] Chem, 2018, vol. 4, # 3, p. 522 - 532
[2] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 8, p. 1149 - 1153
[3] Journal of the American Chemical Society, 1945, vol. 67, p. 1416,1417
[4] Journal of the American Chemical Society, 1941, vol. 63, p. 2435
[5] Journal of the American Chemical Society, 1945, vol. 67, p. 1416,1417