35335-16-1

基本信息
1,4-DIBROMO-2,5-BIS(BROMMETHYL)BENZENE
1,4-Dibromo-2,5-bis(bromomethyl)benzene
2,5-Bis(Bromomethyl)-1,4-dibromobenzene
4-(Bromomethyl)-2,5-dibromobenzyl bromide
1,4-Bis(bromomethyl)-2,5-dibromobenzene97%
Benzene, 1,4-dibromo-2,5-bis(bromomethyl)-
1,4-Dibromo-2,5-bis(bromomethyl)benzene>
1,4-Bis(bromomethyl)-2,5-dibromobenzene 97%
2,5-Bis(bromomethyl)-1,4-dibromobenzene 97%
物理化學性質(zhì)
安全數(shù)據(jù)
常見問題列表
1,4-二溴-2,5-雙(溴甲基)苯用作有機、醫(yī)藥中間體。

1074-24-4

35335-16-1
以2,5-二溴-1,4-二甲基苯為原料合成1,4-二溴-2,5-雙(溴甲基)苯的一般步驟:將2,5-二溴-對二甲苯(26.4 g,0.1 mol)和N-溴代琥珀酰亞胺(NBS,39 g,0.22 mol)懸浮于四氯化碳(300 mL)中,加入過氧化苯甲酰(0.6 g)作為引發(fā)劑。在反應開始前,通入氮氣流鼓泡5分鐘以排除氧氣。隨后,將反應混合物置于100℃的油浴中加熱回流2小時。反應完成后,加入乙醇(200 mL)以沉淀產(chǎn)物,過濾收集固體。用乙醇(50 mL)洗滌固體以去除殘余的反應物和副產(chǎn)物,最后在真空下干燥,得到1,4-二溴-2,5-雙(溴甲基)苯,為白色固體(13.36 g,產(chǎn)率31.6%)。產(chǎn)物結(jié)構(gòu)經(jīng)1H-NMR(500 MHz,CDCl3)確認:δ7.68(s,2H,芳環(huán)氫),4.50(s,4H,溴甲基氫)。
參考文獻:
[1] Tetrahedron Letters, 2007, vol. 48, # 35, p. 6075 - 6079
[2] Organic and Biomolecular Chemistry, 2010, vol. 8, # 24, p. 5620 - 5627
[3] Journal of the American Chemical Society, 2017, vol. 139, # 45, p. 16210 - 16221
[4] Journal of the American Chemical Society, 2017, vol. 139, # 47, p. 17082 - 17088
[5] Journal of the American Chemical Society, 2009, vol. 131, # 49, p. 17724 - 17725