329221-38-7
中文名稱
AX 20017
英文名稱
AX 20017
CAS
329221-38-7
分子式
C13H16N2O2S
分子量
264.34
MOL 文件
329221-38-7.mol
更新日期
2025/07/18 11:13:51
329221-38-7 結(jié)構(gòu)式
基本信息
中文別名
化合物AX200172-(環(huán)丙烷甲酰氨基)-4,5,6,7-四氫苯并[B]噻吩-3-甲酰胺
英文別名
AX 20017PknG Inhibitor
AX-20017
AX 20017
2-(cyclopropanecarboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
Benzo[b]thiophene-3-carboxamide, 2-[(cyclopropylcarbonyl)amino]-4,5,6,7-tetrahydro-
物理化學(xué)性質(zhì)
儲存條件Keep in dark place,Inert atmosphere,2-8°C
溶解度DMSO : ≥ 32 mg/mL (121.06 mM)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
AX20017是蛋白激酶G (PknG) 的小分子抑制劑，IC50 值為 0.39 μM。靶點
IC50: 0.39 μM (PknG)
體外研究
The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.