31750-48-8
中文名稱
他莫昔芬EP雜質(zhì)F
英文名稱
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
CAS
31750-48-8
分子式
C25H27NO
分子量
357.49
MOL 文件
31750-48-8.mol
更新日期
2023/03/20 15:41:27
31750-48-8 結(jié)構(gòu)式
基本信息
中文別名
去甲基他莫昔芬他莫昔芬EP雜質(zhì)F
檸檬酸他莫昔芬EP雜質(zhì)F
英文別名
ici55,548desmethyltamoxifen
n-desmethyltamoxifen
Tamoxifen EP Impurity F
N-DESMETHYL TAMOXIFEN HCL
N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin
2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin
cis-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-n-methylethylamine
物理化學(xué)性質(zhì)
沸點(diǎn)485.8±33.0 °C(Predicted)
密度1.047±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 72 mg/mL (201.40 mM);Ethanol: 36 mg/mL (100.70 mM)
酸度系數(shù)(pKa)9.38±0.10(Predicted)
水溶解性水：不溶
他莫昔芬EP雜質(zhì)F價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2025/05/22 | HY-129099A | 他莫昔芬EP雜質(zhì)F N-Desmethyltamoxifen hydrochloride | 31750-48-8 | 1 mg | 450元 |
| 2025/05/22 | HY-129099A | 他莫昔芬EP雜質(zhì)F N-Desmethyltamoxifen hydrochloride | 31750-48-8 | 10mM * 1mLin DMSO | 780元 |
| 2025/05/22 | HY-129099A | 他莫昔芬EP雜質(zhì)F N-Desmethyltamoxifen hydrochloride | 31750-48-8 | 5mg | 900元 |
常見問題列表
生物活性
N-Desmethyltamoxifen 是 Tamoxifen 在人體內(nèi)的主要代謝產(chǎn)物。N-Desmethyltamoxifen，較弱的抗雌激素，是一種比 Tamoxifen 強(qiáng)十倍的蛋白激酶 C (PKC) 抑制劑。N-Desmethyltamoxifen 也是人體 AML 細(xì)胞神經(jīng)酰胺代謝的有效調(diào)節(jié)因子，限制神經(jīng)酰胺糖基化、水解和鞘氨醇磷酸化。靶點(diǎn)
|
PKC
|
Estrogen Receptor
|
體外研究
N-desmethyltamoxifen (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
N-desmethyltamoxifen (1.5-10 μM; 114 hours) inhibits growth of MCF 7 human mammary carcinoma cells.
N-desmethyltamoxifen, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen.
Cell Viability Assay
| Cell Line: | MCF 7 human mammary carcinoma cells |
| Concentration: | 1.5, 2.5, 5, 7.5, 10 μM |
| Incubation Time: | 114 hours |
| Result: | Inhibits growth of MCF 7 human mammary carcinoma cells |