31224-82-5

基本信息
5-(三氟甲基)-2-吡啶甲酸基醛
5-(三氟甲基)吡啶-2-甲醛,95%
Picolinaldehyde, 5-(trifluoromethyl)-
5-Trifluoromethyl-2-pyridinecarbaldehyde
5-Trifluoromethyl-pyridine-2-carbaldehyde
2-Pyridinecarboxaldehyde, 5-(trifluoromethyl)-
5-(Trifluoromethyl)pyridine-2-carboxaldehyde,95%
5-Trifluoromethyl-pyridine-2-carbaldehyde ISO 9001:2015 REACH
5-Trifluoromethyl-Pyridine-2-Carbaldehyde 5-Trifluoromethyl-Pyridine-2-Carbaldehyde
物理化學(xué)性質(zhì)
常見問題列表

31181-84-7

31224-82-5
以5-三氟甲基吡啶-2-甲醇為原料合成5-三氟甲基吡啶-2-甲醛的一般步驟:將實施例34B(3.89g,22.0mmol)的二氯甲烷(10mL)溶液加入到Dess-Martin periodinane(1,1,1-三(乙酰氧基)-1,1-二氫-1,2-苯并碘氧雜環(huán)戊-3(1H)-酮,10.3g,24.2mmol)的二氯甲烷(73mL)溶液中。在氮氣保護(hù)下,于室溫攪拌反應(yīng)混合物約20分鐘,直至固體形成。用50mL二氯甲烷稀釋反應(yīng)混合物,并小心加入約30mL飽和碳酸氫鈉溶液以淬滅反應(yīng)。過濾除去未溶解的固體,將濾液轉(zhuǎn)移至分液漏斗中。水相用二氯甲烷萃取,合并的有機層用鹽水洗滌,無水硫酸鈉干燥,過濾后減壓濃縮至50mL。將濃縮液通過硅膠柱(Analogix? 40×150mm)進(jìn)行純化,以25%至50%乙酸乙酯/己烷為洗脫劑。最終得到2.86g(產(chǎn)率74%)的5-三氟甲基吡啶-2-甲醛,為透明油狀物,靜置后固化。1H NMR(300MHz,CDCl3)δ10.15(s,1H),9.06(m,1H),8.15(m,1H),8.09(d,J=8.1Hz,1H)。
參考文獻(xiàn):
[1] Patent: US2009/124666, 2009, A1. Location in patent: Page/Page column 26
[2] Patent: US2006/223837, 2006, A1. Location in patent: Page/Page column 35
[3] Patent: US2015/232460, 2015, A1. Location in patent: Paragraph 0478-0480