2421187-89-3
中文名稱
(S,R,S)-AHPC-2-2-6-酸
英文名稱
INDEX NAME NOT YET ASSIGNED
CAS
2421187-89-3
分子式
C33H48N4O8S
分子量
660.83
MOL 文件
2421187-89-3.mol
2421187-89-3 結(jié)構(gòu)式
應(yīng)用領(lǐng)域
用途一
NDN87893, also known as (S,R,S)-AHPC-PEG2-butyl CO2H, is a ProTAC building block. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant carboxylic acid for reactivity with an amine on the target ligand. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate ProTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. This product has no formal name at the moment.