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2349368-16-5

中文名稱 Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-
英文名稱 Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-
CAS 2349368-16-5
分子式 C25H20F7NO4S
分子量 563.48
MOL 文件 2349368-16-5.mol
2349368-16-5 結(jié)構(gòu)式 2349368-16-5 結(jié)構(gòu)式

基本信息

中文別名
XY101
化合物 T13362
英文別名
XY101
Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-

物理化學(xué)性質(zhì)

沸點(diǎn)682.4±55.0 °C(Predicted)
密度1.439±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 250 mg/mL (443.67 mM)
酸度系數(shù)(pKa)8.87±0.19(Predicted)
形態(tài)Solid
顏色Off-white to light yellow

應(yīng)用領(lǐng)域

用途一
XY101 is a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer with IC50 = 30nM. XY101 potently inhibited cell growth, colony formation, and the expression of AR, AR-V7, and PSA. XY101 also exhibited good metabolic stability and a pharmacokinetic profile with oral bioavailability of 59% and a half-life of 7.3 h. Notably, XY101 demonstrated promising therapeutic effects with significant tumor growth inhibition in a prostate cancer xenograft model inmice.

常見(jiàn)問(wèn)題列表

概述
XY101 是一種有效選擇性的、代謝穩(wěn)定的口服 RORγ 反向激動(dòng)劑,IC50 為 30 nM,Kd 為 380 nM。
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