2241014-82-2
中文名稱(chēng)
NAMPT inhibitor-linker 2
英文名稱(chēng)
NAMPT inhibitor-linker 2
CAS
2241014-82-2
分子式
C34H33FN6O5
分子量
624.66
MOL 文件
2241014-82-2.mol
2241014-82-2 結(jié)構(gòu)式
基本信息
中文別名
4-(4-(3-(2,5-二氧代-2,5-二氫-1H-吡咯-1-基)丙?；?哌嗪-1-基)-N-(2-氟-4-((1S,2S)-2-(吡啶-3-基)環(huán)丙烷-1-甲酰胺基)芐基)苯甲酰胺 英文別名
NAMPT inhibitor-linker 2Benzamide, 4-[4-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-1-piperazinyl]-N-[[2-fluoro-4-[[[(1S,2S)-2-(3-pyridinyl)cyclopropyl]carbonyl]amino]phenyl]methyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)940.2±65.0 °C(Predicted)
密度1.395±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)13.91±0.70(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
NAMPT inhibitor-linker 2價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/05/22 | HY-112616 | NAMPT inhibitor-linker 2 | 2241014-82-2 | 1 mg | 1364元 |
| 2025/05/22 | HY-112616 | NAMPT inhibitor-linker 2 | 2241014-82-2 | 5 mg | 3000元 |
| 2025/05/22 | HY-112616 | NAMPT inhibitor-linker 2 | 2241014-82-2 | 10 mg | 4800元 |
常見(jiàn)問(wèn)題列表
生物活性
NAMPT inhibitor-linker 2 為 ADC 的一部分，由一種 NAMPT 的抑制劑作為有效載荷和一個(gè)連接物組成。ADC-4 由一個(gè) NAMPT inhibitor-linker 2 和一個(gè) anti-c-Kit 單克隆抗體組成，對(duì)表達(dá) c-Kit 的細(xì)胞具有抑制作用，比如 GIST-T1 和 NCI-H526 細(xì)胞，IC50 值分別為 <7 pM 和 40 pM。靶點(diǎn)
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Traditional Cytotoxic Agents
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體外研究
ADC-4 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC
50
s of <7 pM and 40 pM, respectively.
ADC-4 (0.01 nM-10 nM, 144 hours) inhibits cell proliferation of GIST-T1 cells, but does not affect the cell cycle.
Cell Proliferation Assay
| Cell Line: | GIST-T1 cells |
| Concentration: | 0.1 pM-10 nM |
| Incubation Time: | 144 hours |
| Result: | Inhibited the cell proliferation of GIST-T1 cells at 0.01-10 nM, and the inhibition remained unchanged after 1 nM. |
體內(nèi)研究
ADC-4 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells.
| Animal Model: | Female scid-beige (SCID bg) mice |
| Dosage: | 20 mg/kg |
| Administration: | A single intravenous injection (i.v.) for 28 days |
| Result: | Significantly inhibited the growth of tumor in mice. |