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221054-79-1

中文名稱 R-雌馬酚
英文名稱 R-Equol
CAS 221054-79-1
分子式 C15H14O3
分子量 242.27
MOL 文件 221054-79-1.mol
更新日期 2025/06/10 14:47:47
221054-79-1 結構式 221054-79-1 結構式

基本信息

中文別名
R-雌馬酚
ERΑ和ERΒ激動劑((R)-EQUOL)
英文別名
R-Equol
Isoequol
(R)-Equol,99%e.e.
(R)-Equol Exclusive
(3R)-3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol

物理化學性質

熔點184-187 °C
沸點441.7±45.0 °C(Predicted)
密度1.286±0.06 g/cm3(Predicted)
溶解度DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
酸度系數(shù)(pKa)9.94±0.40(Predicted)
形態(tài)結晶固體
顏色White to yellow
R-雌馬酚價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2025/05/22HY-108414R-雌馬酚
(R)-Equol
221054-79-15mg770元
2025/05/22HY-108414R-雌馬酚
(R)-Equol
221054-79-110mM * 1mLin DMSO847元
2025/05/22HY-108414R-雌馬酚
(R)-Equol
221054-79-110mg1350元

常見問題列表

生物活性
(R)-Equol 是 ERα 和 ERβ 的激動劑,Ki 值分別為 27.4 和 15.4 nM。
靶點

Ki: 27.4 nM (ERα), 15.4 nM (ERβ)

體外研究

(R)-Equol is an agonist of both ERα and ERβ with K i s of 27.4 and 15.4 nM, respectively. (R)-Equol induces a dose-dependent inhibitory effect on the invasive capacity of MDA-MB-231 cells that is significant at the highest concentration tested (50 μM). Following 48-h exposure to (R)-Equol, invasion is reduced by 62% (p=0.009, versus untreated cells) with 50 μM (R)-Equol. Matrix metalloproteinase-2 (MMP-2) expression is significantly down-regulated following treatment with 50 μM (R)-Equol (p=0.035).

體內研究

Animals fed (R)-Equol have a significantly reduced number of palpable tumors over time when compare with Controls (P=0.002). Furthermore, the number of palpable tumors formed per rat in the (R)-Equol-fed group is significantly lower than that of rats treated with S-(-)equol (P=0.008). (R)-Equol-fed animals have 43% fewer tumors than the control group and this difference is highly statistically significant (P=0.004). The number of tumors/tumor-bearing animal is significantly lower in the animals fed (R)-Equol compare with Controls (3.3±0.4 versus 5.5±0.5, P=0.004). At necropsy, the mean (±SEM) tumor weight per animal for (R)-Equol fed rats (5.3±1.1 mg) is significantly reduced (P=0.04) when compare with Controls (9.9±1.4 mg). Feeding the (R)-Equol diet results in significantly increased tumor latency (P=0.003).

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