217448-86-7

基本信息
盧非酰胺相關(guān)物質(zhì)B
魯芬酰胺EP雜質(zhì)B
盧非酰胺雜質(zhì)B(USP)
盧非酰胺USP相關(guān)化合物B
盧非酰胺相關(guān)化合物B(USP)
4-去甲酰胺基盧非酰胺 4-甲酯
盧非酰胺相關(guān)物質(zhì)B USP標(biāo)準(zhǔn)品
RUFINAMIDE USP相關(guān)化合物B
1-(2,6-二氟芐基)-1H-1,2,3-三唑-4-羧酸甲酯
Rufinamide EP Impurity B
Rufinamide 4-Methyl Ester
RufinaMide Related CoMpound B
Rufinamide Methyl Ester Analog
Rufinamide USP Related Compound B
Methyl 1-(2,6-Difluorobenzyl)-1H-1,
methyl 1-[(2,6-difluorophenyl)methyl]triazole-4-carboxylate
Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate
Rufinamide Related Compound B (Rufinamide Methyl Ester Analog)
物理化學(xué)性質(zhì)
制備方法

106308-60-5

922-67-8

217448-86-7
實(shí)施例7:化合物(II)的合成 1-[(2,6-二氟苯基)甲基]-1H-1,2,3-三唑-4-羧酸甲酯的合成:將2,6-二氟芐基疊氮化物(3.0克,17.7毫摩爾)懸浮于乙醇(30毫升)中,隨后加入丙炔酸甲酯(1.6克,19.6毫摩爾)、抗壞血酸(317毫克,1.8毫摩爾)及五水合硫酸銅(50毫克,0.18毫摩爾)。反應(yīng)混合物在25℃下攪拌過夜。反應(yīng)完成后,將混合物濃縮,用乙酸乙酯溶解,所得溶液用氨水洗滌。有機(jī)相經(jīng)干燥、過濾后,減壓濃縮,得到白色結(jié)晶固體,收率為94%。 1H NMR(400MHz,DMSO-d6)δ(ppm):8.86(s,1H),7.52(m,1H),7.27-7.12(m,2H),5.74(s,2H),3.83(s,3H)。
參考文獻(xiàn):
[1] Patent: US2010/234616, 2010, A1. Location in patent: Page/Page column 3
[2] Patent: EP2230234, 2010, A1. Location in patent: Page/Page column 7
[3] ChemSusChem, 2015, vol. 8, # 3, p. 504 - 512
[4] Patent: WO2010/43849, 2010, A1. Location in patent: Page/Page column 13
[5] Tetrahedron Letters, 2013, vol. 54, # 26, p. 3406 - 3409