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216167-92-9

中文名稱(chēng) 216167-92-9
英文名稱(chēng) CAMOBUCOL
CAS 216167-92-9
分子式 C33H50O4S2
分子量 574.88
MOL 文件 216167-92-9.mol
216167-92-9 結(jié)構(gòu)式 216167-92-9 結(jié)構(gòu)式

基本信息

中文別名
化合物 T14861
英文別名
CAMOBUCOL
AGIX 4207
Acetic acid,2-[4-[[1-[[3,5-bis(1,1-diMethylethyl)-4-hydroxyphenyl]thio]-1-Methylethyl]thio]-2,6-bis(1,1-diMethylethyl)phenoxy]-

物理化學(xué)性質(zhì)

熔點(diǎn)164-165 °C
沸點(diǎn)622.6±55.0 °C(Predicted)
密度1.11±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)3.23±0.10(Predicted)
形態(tài)Solid
顏色White to yellow
216167-92-9價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2025/05/22HY-14916Camobucol216167-92-91 mg1818元
2025/05/22HY-14916216167-92-9
Camobucol
216167-92-95mg4000元
2025/05/22HY-14916Camobucol216167-92-910 mM * 1 mLin DMSO5059元

常見(jiàn)問(wèn)題列表

生物活性
Camobucol (AGIX 4207) 是一種可口服的酚類(lèi)抗氧化劑和抗炎劑,用于風(fēng)濕病的研究。
體外研究

Camobucol exhibits potent antioxidant activity toward lipid peroxides in vitro and displays enhanced cellular uptake. Camobucol selectively inhibits tumor necrosis factor (TNF)-α-inducible levels of the redox-sensitive genes, vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1, with less inhibition of E-selectin, and no effect on intracellular adhesion molecule-1 expression in endothelial cells. In addition, Camobucol inhibits cytokine-induced levels of monocyte chemoattractant protein-1, interleukin (IL)-6, and IL-8 from endothelial cells and human fibroblast-like synoviocytes as well as lipopolysaccharide-induced release of TNF-α, IL-1β, and IL-6 from human peripheral blood mononuclear cells. Camobucol does not inhibit TNF-α-induced nuclear translocation of nuclear factor of the κ-enhancer in B cells (NF-κB), suggesting that the mechanism of action is independent of this redox-sensitive transcription factor.

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