2140-67-2

基本信息
N2,N2-二甲基鳥苷
M(2/2) GUO
2-(DIMETHYLAMINO)GUA
2,2-DiMethylguanosine
N,N-Dimethylguanosine
N2,N2-DIMETHYLGUANOSINE
2-(DIMETHYLAMINO)GUANOSINE
2-Dimethylamino-D-guanosine
N(sup 2),N(sup 2)-dimethylguanosine
2-DiMethylaMino-6-oxypurine Riboside
物理化學(xué)性質(zhì)
常見問題列表

73196-87-9

2140-67-2
將化合物1(CAS: 73196-87-9,1.5 g,3.4 mmol)溶解于吡啶(2 mL)中,隨后加入氨水。反應(yīng)混合物在室溫下攪拌3小時(shí),通過薄層色譜(TLC)監(jiān)測(cè)反應(yīng)進(jìn)度,直至顯示完全脫保護(hù)。反應(yīng)完成后,將溶劑在減壓下蒸發(fā)至干。粗產(chǎn)物通過從水中重結(jié)晶進(jìn)行純化,得到目標(biāo)產(chǎn)物9-((2R,3R,4S,5R)-3,4-二羥基-5-(羥甲基)四氫呋喃-2-基)-2-(二甲氨基)-1,9-二氫-6H-嘌呤-6-酮,產(chǎn)量0.68 g,收率65%。產(chǎn)物的結(jié)構(gòu)通過1H NMR、13C NMR和質(zhì)譜(ES-TOF)進(jìn)行確認(rèn)。1H NMR (DMSO-d6) δ: 3.06 (6H, s, NMe2), 3.48-3.63 (2H, m, 5'-CH2), 3.86 (1H, q, J = 4 Hz, H4'), 4.11 (1H, q, J = 4 Hz, H3'), 4.50 (1H, q, J = 4 Hz, H2'), 4.91 (1H, t, J = 5.4 Hz, OH5'), 5.15 (1H, d, J = 4.8 Hz, OH3'), 5.38 (1H, d, J = 6.1 Hz, OH2'), 5.71 (1H, d, J = 5.8 Hz, H1'), 5.92 (1H, s, H8), 10.69 (1H, bs, NH); 13C NMR δ: 38.1 (NMe2), 61.8 (C5'), 70.7 (C3'), 73.7 (C2'), 85.4 (C4'), 87.0 (C1'), 100.0, 116.4, 136.8 (C8), 151.1, 153.3, 157.7; MS (ES-TOF) m/z: 計(jì)算值 312.13,實(shí)測(cè)值 312.54。
參考文獻(xiàn):
[1] Journal of Organic Chemistry, 1991, vol. 56, # 3, p. 1224 - 1227
[2] Journal of Organic Chemistry, 1996, vol. 61, # 13, p. 4412 - 4422
[3] Patent: US9067964, 2015, B2. Location in patent: Page/Page column 15
Human Endogenous Metabolite
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報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2025/05/22 | HY-113137 | N2,N2-二甲基鳥苷 N2,N2-Dimethylguanosine | 2140-67-2 | 1 mg | 300元 |
2025/05/22 | HY-113137 | N2,N2-二甲基鳥苷 N2,N2-Dimethylguanosine | 2140-67-2 | 5mg | 600元 |
2025/05/22 | HY-113137 | N2,N2-二甲基鳥苷 N2,N2-Dimethylguanosine | 2140-67-2 | 10mM * 1mLin DMSO | 660元 |