2123489-30-3
中文名稱
ALLOSTERIC WNK KINASE INHIBITOR
英文名稱
Allosteric WNK Kinase Inhibitor ,
CAS
2123489-30-3
分子式
C21H21Cl2N5OS
分子量
462.4
MOL 文件
2123489-30-3.mol
更新日期
2025/08/13 14:38:07
2123489-30-3 結構式
基本信息
中文別名
化合物WNK-IN-115-氯-2-[2-(甲氨基)-4-噻唑基]-4-吡啶基][4-[(4-氯苯基)甲基]-1-哌嗪基]-甲酮
英文別名
WNK-IN-11ALLOSTERIC WNK KINASE INHIBITOR
Allosteric WNK Kinase Inhibitor ,
WNK-IN-11
WNK IN 11
WNKIN11
WNK INHIBITOR 11
WNK INHIBITOR-11
2123489-30-3
(5-Chloro-2-(2-(methylamino)thiazol-4-yl)pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone
Methanone, [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]-
物理化學性質
沸點641.1±65.0 °C(Predicted)
密度1.407±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml; DMSO: 25 mg/ml; Ethanol: 3 mg/ml
酸度系數(pKa)5.52±0.10(Predicted)
形態(tài)結晶固體
顏色White to off-white
ALLOSTERIC WNK KINASE INHIBITOR價格(試劑級)
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | S0015 | ALLOSTERIC WNK KINASE INHIBITOR WNK-IN-11 | 2123489-30-3 | 5mg | 3550.96元 |
| 2025/05/22 | S0015 | WNK-IN-11 | 2123489-30-3 | 10mM (1mL in DMSO) | 3990元 |
| 2025/05/22 | HY-112094 | WNK-IN-11 | 2123489-30-3 | 1 mg | 920元 |
常見問題列表
生物活性
WNK-IN-11 是一種有效的、具有選擇性的 With-No-Lysine (WNK) 的口服活性變構抑制劑，對WNK1酶的IC50為4 nM。靶點
| Target | Value |
|
WNK1
(Cell-free assay) | 4 nM |
體外研究
WNK-IN-11 (compound 11) shows IC 50 <2 μM in the cellular OSR1 phosphorylation assay with reasonable aqueous solubility, albeit with still rather high microsomal clearance. WNK-IN-11 shows ATP noncompetitive inhibition. When tested against a panel of 440 human kinases at 10 μM concentration, 2500-fold above enzyme IC 50 value, WNK-IN-11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and feline encephalitis virus-related (FER) kinase, neither of which are implicated for blood pressure regulation. This excellent selectivity profile is consistent with the predicted allosteric binding mode outside the highly conserved ATP-pocket.