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2093088-81-2

中文名稱 化合物 T27319
英文名稱 2-Propenamide, N-[3-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-
CAS 2093088-81-2
分子式 C35H38N8O4
分子量 634.73
MOL 文件 2093088-81-2.mol
2093088-81-2 結(jié)構(gòu)式 2093088-81-2 結(jié)構(gòu)式

基本信息

中文別名
化合物 T27319
英文別名
2-Propenamide, N-[3-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-

物理化學(xué)性質(zhì)

密度1.306±0.06 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度DMSO: 10mg/mL, clear
酸度系數(shù)(pKa)13.54±0.70(Predicted)
形態(tài)powder
顏色white to beige

應(yīng)用領(lǐng)域

用途一
FIIN-4 is a first-in-class covalent inhibitor of FGFR (Fibroblast Growth Factor Receptor) that inhibits metastatic breast cancer. Structurally, FIIN-4 is an regional isomer of FIIN-2 (Cat#406652). FIIN-4 effectively blocks 3D metastatic outgrowth as compared with currently available FGFR inhibitors. In vivo application of FIIN-4 potently inhibited the growth of metastatic, patient-derived breast cancer xenografts and murine-derived metastases growing within the pulmonary microenvironment. (Copied from Mol Cancer Ther. 2016 Sep;15(9):2096-106. )

常見問題列表

概述
FIIN-4 是一種小分子半胱氨酸靶向共價(jià)激酶 (CKI) 抑制劑。
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