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1876450-21-3

中文名稱 1876450-21-3
英文名稱 MM 07
CAS 1876450-21-3
分子式 C67H106N22O14S3
分子量 1539.91
MOL 文件 1876450-21-3.mol
1876450-21-3 結(jié)構(gòu)式 1876450-21-3 結(jié)構(gòu)式

基本信息

中文別名
激動(dòng)劑多肽MM 07
APELIN受體多肽
英文別名
MM 07
所屬類別
生物化工:多肽

物理化學(xué)性質(zhì)

密度1.52±0.1 g/cm3(Predicted)
儲(chǔ)存條件Store at -20° C
酸度系數(shù)(pKa)3.56±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
水溶解性Souble in water
MM 07價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/05/22HY-1080031876450-21-3
MM 07
1876450-21-31mg640元
2025/05/22HY-1080031876450-21-3
MM 07
1876450-21-35mg1600元
2025/05/22HY-1080031876450-21-3
MM 07
1876450-21-310mg2400元

常見(jiàn)問(wèn)題列表

生物活性
MM 07 是一種有偏倚性的 apelin 受體 (apelin receptor) 激動(dòng)劑,在 CHO-K 細(xì)胞中的 KD 值為 300 nM,在人心臟中的 KD 值為 172 nM。
靶點(diǎn)

KD: 300 nM (apelin receptor in CHO-K1 cells), 172 nM (apelin receptor in human heart).

體外研究

MM 07 competes with nanomolar affinities for binding of [Glp 65 ,Nle 75 ,Tyr 77 ] [ 125 I]apelin-13 to human apelin receptors in CHO-K1 cells (K D , 300 nM) and human heart (K D , 172 nM, n=3).

體內(nèi)研究

MM 07 causes a dose-dependent increase in cardiac output, and although there is a decrease in vascular resistance, this is without corresponding effects on BP. Administration of SNAP produces a profound fall in BP in both [Pyr 1 ]apelin-13 and MM 07-treated groups; however, although cardiac output is significantly increased in response to SNAP in the MM 07 group, it is significantly reduced in the [Pyr 1 ]apelin-13 group. Neither peptide causes a significant change in heart rate, respiratory rate, or temperature. Both [Pyr 1 ]apelin 13 and MM 07 increases peak velocity above basal levels.

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